Journal of Liver: Disease & TransplantationISSN: 2325-9612

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Research Article, J Liver Dis Transplant Vol: 1 Issue: 2

Sustained Glutathione Deficiency Interferes with the Liver Response to TNF-α and Liver Regeneration after Partial Hepatectomy in Mice

Kimberly J. Riehle1,2, Jamil Haque2, Ryan S. McMahan2, Terrance J. Kavanagh3, Nelson Fausto2 and Jean S. Campbell2*
1Department of Surgery, University of Washington, Seattle, WA, USA
2Department of Pathology, University of Washington, Seattle, WA, USA
3Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA
Corresponding author : Jean S. Campbell, PhD
Department of Pathology, University of Washington, 1959 NE Pacific Street, Box 357705, Seattle, WA 98195-7705, USA
Tel: 206-616-4796; Fax: 206-616-1943
E-mail: [email protected]
Received: November 14, 2012 Accepted: January 10, 2013 Published: January 12, 2013
Citation: Riehle KJ, Haque J, McMahan RS, Kavanagh TJ, Fausto N, et al. (2012) Sustained Glutathione Deficiency Interferes with the Liver Response to TNF-α and Liver Regeneration after Partial Hepatectomy in Mice. J Liver: Dis Transplant 1:2. doi:10.4172/2325-9612.1000105

Abstract

Sustained Glutathione Deficiency Interferes with the Liver Response to TNF-α and Liver Regeneration after Partial Hepatectomy in Mice

Glutathione (GSH) is a tripeptide of glutamate, cysteine, and glycine. It is the most abundant non-protein thiol in the cell, and is present at 5-10 mM in hepatocytes. GSH scavenges reactive oxygen species (ROS) and acts as a cofactor in the metabolism of xenobiotics through reduction and conjugation reactions. Several methods have been used in vivo and in vitro to study the effects of short-term GSH depletion on the hepatocyte cell cycle.

Keywords: Hepatocytes; Glutathione; Liver disease; Liver regeneration

Track Your Manuscript

Share This Page