The Journal of Clinical & Experimental Oncology (JCEOG) promotes rigorous research that makes a significant contribution in advancing knowledge for cancer diagnosis and therapy. The journal includes all major themes pertaining to medical oncology, surgery, radiotherapy and pediatric oncology.
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p53 Gene Inactivation Modulate Methylenetetrahydrofolate C677T Gene Polymorphism Associated Risk Factor for the Development of Cervical Carcinoma -A Tissue specific Genetic Heterogeneity
Inconsistently, epidemiological studies reveals that folate regulate a significant role in DNA synthesis and etiopathology of cervical cancer in women. Folate, an essential dietary component require for DNA methylation during cell proliferation. Methylenetetrahydrofolate reductase (MTHFR) catalyzes the synthesis of 5-methylenetetrahydrofolate involved in the methylation of homocysteine to methionine. A common substitution of this enzyme gene variant 677 C → T (Ala → Val) shown to reduced activity results mild hyperhomocysteinemia. We have collected the blood sample from those patients having lack of infection form human papilloma virus (HPV).
Tumor promotion and progression depends on a complex interaction between cellular signaling pathways, apoptosis, angiogenesis and other mechanisms. Understanding these mechanisms and their interactions led to the development of targeted therapies such as antiangiogenic agents and mTOR inhibitors in cancer. In recent years, inhibitors of apoptosis proteins (IAP) like survivin and livin seem promising as new targets for cancer therapy. In this report, the role of survivin and livin with angiogenesis will be discussed.
Encapsulated Minimally Invasive Epimyoepithelial Carcinoma of Submandibular Gland - A New Entity?? With Review of Literature
Epimyoepithelial carcinoma (EMC) is a rare low-grade salivary gland malignancy comprising of 1% of all the salivary glands tumors. EMC is a rare tumor when involving submandibular gland (8.6%) as compared to parotid gland (62.1%). A thorough pubmed literature search retrieved only 17 cases of EMC involving submandibular gland since 1972. EMC can present in classical pattern characterised by biphasic cell population with inner layer of cuboidal to columnar cells and outer layer of myoepithelial cells. Encapsulated minimally invasive epimyoepithelial carcinoma is a recently coined terminology by Seethala et al. To the best of our knowledge, this is the first case of encapsulated minimally invasive EMC of submandibular salivary gland discussed in the literature. The present paper highlights the review of literature of EMC involving submandibular salivary gland, histomorphological spectrum and diagnostic differentiation from other salivary gland tumors.
All of us at some point in our careers get enlightened by our patients regarding even the subtle aspects of the practice of clinical medicine. In one of our routine hectic outpatients, we had this routine referral regarding a lady in her mid fifties with carcinoid syndrome. As the lady was being ushered into the examination bays, I frantically tried to recap the classical symptoms associated with the condition so that I can touch base with the patient before deciding about further management. Mustering what I could from my memory, I went to greet my patient and initiate the consultation. Before I could proceed to elicit the symptoms which I could recollect, the pleasant lady thrust into my hands a neatly typed paper aptly titled ‘Re-actions’ to highlight her symptoms.