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Elastography as a New Screening Tool for Metastatic Lymph Nodes in Melanoma Patients
In melanoma patients, early detection of lymph node recurrence is essential. Elastography is a non-invasive technique for studying tissue stiffness, already used to assess liver, thyroid and breast lesions, pancreatic and prostate nodules and cervical lymphadenopathy. In a prospective pilot study, we
sought to evaluate the value of a combination of elastography and B-mode ultrasonography for detecting lymph node metastases in melanoma patients.
Metabolic Basis of Treatment Failures; Autophagy and Malignant Cancer Progression
Cells use a number of pathways to generate energy and synthesize cellular building blocks including lipids, carbohydrates and nucleotides. Alterations in metabolic pathways have been implicated in many pathophysiological conditions. This mechanism is exploited by both resident epithelial cancer cells and the fibroblast. Indeed, cancer and normal cells differ dramatically in terms of their energy requirements and use of metabolic pathways. Mitochondrial dysfunction and metabolic impairment contribute immensely to chemotherapeutic resistance and metastatic cancer progression through signaling pathways that revolve around autophagy. The current study reviewed relevant studies that underpin autophagy and highlight the metabolic alterations in the tumour microenvironment that may mediate chemoresistance and malignant cancer progression in both experimental and clinical models.
Giant Cell Tumour of Soft Tissue of the Finger: A Case Report
Giant cell tumour of soft tissue resembling osseous giant cell tumour is a distinct and uncommon entity. Presented is a 52-year old man with a 3-year history of swelling located on the dorsum of the right middle finger diagnosed on histology as giant cell tumour of soft tissue. The need for high index of suspicion by physicians is emphasized, as giant cell tumour of soft tissue should be considered as differential diagnosis of finger lumps.
Lung Adenocarcinoma Presenting with WDHA Syndrome and Marie-Bamberger Syndrome: A Case
Watery diarrhea, hypokalemia, and achlorhydria (WDHA syndrome), also known as Vermer-Morrison syndrome or vipoma syndrome, was first reported by Verner and Morrison in 1958. It is characterized by watery diarrhea, hypokalemia and achlorhydria (or metabolic acidosis), most commonly associated with pancreatic islet cell tumors in adults.