Parmit Kumar Singh
National Institutes of Health
Michael D George
University of California
Albert Einstein College of Medicine
Getachew A Dagne
University of South Florida
Journal of Primary & Acquired Immunodeficiency Research is a peer-reviewed scholarly journal that aims to publish the most complete and reliable source of information on the discoveries and current developments in the form of original articles, full/mini reviews, case reports, commentaries, letter to editor, rapid/short communications, etc. in all areas pertaining to Immunodeficiency, making them available online freely without any restrictions or subscription to researchers worldwide.
Journal of Primary & Acquired Immunodeficiency Research publishes results of research on, but not limited to, the following topics:
The Journal uses Editorial Manager System to maintain quality review process. Editorial Manager is an online manuscript submission, review and tracking system. Review process is performed by the editorial board members of Journal of Primary & Acquired Immunodeficiency Research or outside experts; the validation by at least two independent reviewers followed by the editor’s approval is required for the acceptance of any citable manuscript for publication in the Journal. Authors may submit manuscripts and track its progress through the system, hopefully to publication. Reviewers can download manuscripts and submit their opinions to the editor in the Editorial Manager System. Editors can manage the entire submission/review/revision/publication process.
Immunology is the branch of biomedical science that deals with the response of an organism to antigenic challenge and its recognition of what is self and non-self. It deals with the defense mechanisms including all physical, chemical and biological properties of the organism that help it to combat its susceptibility to foreign organisms, material, etc. Immunology deals with physiological functioning of the immune system in both health and disease state as well as malfunctions of the immune system in immunological disorders. Immunology deals with physical, chemical and physiological characteristics of the components of the immune system in vitro, in situ, and in vivo. Immunology has a vast array of uses in several disciplines of science and medical science.
Related Journals of Immunology:
Mucosal Immunology, Open Biology, Seminars in Immunology, Annals of the Rheumatic Diseases, Seminars in Immunopathology, Journal of Immunology, Journal of Virology, Cytokine and Growth Factor Reviews, Cellular Microbiology, Biology Direct, Brain, Behavior, and Immunity, Journal of Neuroinflammation, European Journal of Immunology, Allergy: European Journal of Allergy and Clinical Immunology, Journal of Leukocyte, Biology Arthritis and Rheumatism, Immunology and Cell Biology, Cell death & disease, Frontiers in Immunology
The immune system is a system of many biological structures and processes within an organism that protects against disease. To function properly, an immune system must detect a wide variety of agents, known as pathogens, from viruses to parasitic worms, and distinguish them from the organism's own healthy tissue. Your immune system does a remarkable job of defending you against disease-causing microorganisms. The immune system is made up of a network of cells, tissues, and organs that work together to protect the body. One of the important cells involved are white blood cells, also called leukocytes, which come in two basic types that combine to seek out and destroy disease-causing organisms or substances. The immune system is divided into those which are static, or innate to the organism, and those which are responsive, or adaptive to a potential pathogen or foreign substance.
Related Journals of Immune System:
Annual Review of Immunology, Nature Reviews Immunology, Nature Immunology,Immunity, Journal of Experimental Medicine, Trends in Immunology, Immunological Reviews,International Reviews of Immunology, Clinical and Experimental Allergy Immunology, Immunome Research
Primary immunodeficiency disorders also called primary immune disorders or primary immunodeficiency weaken the immune system, allowing infections and other health problems to occur more easily. Many people with primary immunodeficiency are born missing some of the body's immune defenses, which leaves them more susceptible to germs that can cause infections. Some forms of primary immunodeficiency are so mild they may go unnoticed for years. Other types are severe enough that they're discovered almost as soon as an affected baby is born. Treatments can boost the immune system for many types of primary immunodeficiency disorders. Most people with the condition lead relatively normal, productive lives. Researchers have identified more than 150 different types of primary immunodeficiency disease (also known as primary immune deficiency disease).
Related Journals of Primary Immunodeficiecny:
European Journal of Immunology, Allergy: European Journal of Allergy and Clinical Immunology, Frontiers in Immunology, Critical Reviews in Immunology, Infection and Immunity, International Reviews of Immunology, Clinical and Experimental Allergy, Immunology
Secondary immunodeficiency is a result of failure of components of the immune system that are mainly involved in protecting against infection. This may be a failure of production of immune cells or, although cell numbers are normal, they do not function well. Secondary immunodeficiency can occur from many causes including, treatment for certain cancers (lymphoma, lymphocytic leukemia) by radiation, drug therapy or bone marrow transplant for cancer, treatment by bone marrow transplant for other non-cancer conditions such as metabolic disease or treatment by bone marrow transplant for other non-cancer conditions such as metabolic disease
Related Journals of Secondary Immunodeficiency:
Journal of HIV/AIDS Prevention in Children and Youth, The AIDS Reader, The Open AIDS Journal, World Journal of AIDS, Current Opinion in HIV and AIDS, International Reviews of Immunology, Clinical and Experimental Allergy, Immunology, Immunome Research
Immunodeficiency disorders involve malfunction of the immune system, resulting in infections that develop and recur more frequently, are more severe, and last longer than usual. Immunodeficiency disorders usually result from use of a drug or from a long-lasting serious disorder (such as cancer) but occasionally are inherited. Immunodeficiency disorders impair the immune system’s ability to defend the body against foreign or abnormal cells that invade or attack it (such as bacteria, viruses, fungi, and cancer cells). As a result, unusual bacterial, viral, or fungal infections or lymphomas or other cancers may develop.
Related Journals of Immunodeficiency Disorders:
Endocrine, Metabolic & Immune Disorders - Drug Targets, Journal of immunodeficiency & disorders, Allergy, Asthma & Clinical Immunology, The Journal of Allergy and Clinical Immunology, LymphoSign Journal, Frontiers in Immunology, Clinical Immunology, Immunology and Allergy Clinics of North America, Ophthalmology, Egyptian Journal of Chest Diseases and Tuberculosis
One of the most common signs of immunodeficiency is an increased susceptibility to infections. You may have infections that are more frequent, longer lasting or harder to treat than are the infections of someone with a normal immune system. You may also get infections that a person with a healthy immune system likely wouldn't get (opportunistic infections).Signs and symptoms differ depending on the type of immunodeficiency disorder, and they vary from person to person.
Related Journals of Immunodeficiency Symptoms:
Current Opinion in HIV and AIDS, International Reviews of Immunology, Clinical and Experimental Allergy, Immunology, Immunome Research, The American Journal of Medicine, International Journal of Antimicrobial Agents, Journal of Pain and Symptom Management, Journal of Allergy and Clinical Immunology, Clinical Immunology, BMC Immunology, Journal of Medical Case Reports
AIDS stands for Acquired Immune Deficiency Syndrome: Acquired means you can get infected with it; Immune Deficiency means a weakness in the body's system that fights diseases. Syndrome means a group of health problems that make up a disease. AIDS is the final and most serious stage of HIV disease, which causes severe damage to the immune system. AIDS is a condition caused by a virus called HIV. This virus attacks the immune system of the body that fights off infections. When the immune system breaks down, person loses this protection and can develop many serious, often deadly diseases. These are called opportunistic infections (OIs) because they take advantage of the body's week immune system.
Related Journals of AIDS:
Journal of AIDS and HIV Research, Journal of AIDS/HIV (A Journal Digest of Current Therapy for AIDS and HIV ), Journal of HIV/AIDS & Social Services, Journal of HIV/AIDS Prevention & Education for Adolescents & Children, Journal of HIV/AIDS Prevention in Children and Youth, The AIDS Reader, The Open AIDS Journal, World Journal of AIDS AIDS Research and Human Retroviruses
For each organ in the mature body, there are specific stem cells that can make all the different kinds of cells in that organ. For example, in the blood system, hematopoietic (blood-forming) stem cells (HSC) give rise to each of the different types of blood cells such as red blood cells (RBC), white blood cells (WBC) and platelets. Traditionally, HSCs were obtained from the bone marrow. This process was called “bone marrow transplantation.” However, new methods now obtain HSC from peripheral blood, or blood taken from the placenta at birth (cord blood). Cord blood, in particular, provides an excellent alternative source of HSC for the immune and blood systems. The process of taking HSCs from one person and transfusing them into another is called hematopoietic stem cell transplantation, or HSCT. Unlike transplantation of a solid organ (such as a kidney or liver), HSCT does not involve surgery. It is more similar to a blood transfusion. But instead of just blood, the fluid transfused contains HSCs. The primary immunodeficiency diseases for which HSCT is most commonly performed include Severe Combined Immune Deficiency (SCID), Wiskott-Aldrich Syndrome (WAS), IPEX Syndrome, Hemophagocytic Lymphohistiocytosis (HLH) and X-linked Lymphoproliferative Disease (XLP). It can also be used in the treatment of Chronic Granulomatous Disease (CGD) and many other severe primary immunodeficiency diseases. The transplantation of HSCs from a “normal” individual to an individual with a primary immunodeficiency disease has the potential to replace the deficient immune system of the patient with a normal immune system and, thereby, affect a cure.
Related Journals of Hematopoietic Stem Cell Transplantation:
Blood, Journal of Hematopoietic Cell Transplantation, Biology of Blood and Marrow Transplant, Journal of Hematology & Oncology, The New England Journal of Medicine, The Journal of Allergy and Clinical Immunology, Nature Reviews Cancer, The Journal of American Medical Association, Bone Marrow Research, Bone Marrow Transplantation
Immunodiagnostics is a diagnostic methodology that uses an antigen-antibody reaction as their primary means of detection. The concept of using immunology as a diagnostic tool was introduced in 1960 as a test for serum insulin. Immunodiagnostic tests use antibodies as reagents whose results are used to aid diagnosis and are widely used in many scientific disciplines. Perhaps the most widespread and obvious use is in clinical applications, but immunodiagnostic tests are also used in other fields such as forensic science and environmental and food analysis. The different types of test range from simple manual methods to fully automated systems with sophisticated integrated detection.
Related Journals of Immunodiagnostics:
Journal of Molecular Diagnostics, Diagnostic Microbiology and Infectious Disease, Expert Review of Molecular Diagnostics, Diagnostic Molecular Pathology, Journal of Clinical and Diagnostic Research, Introductory Immunology, Neuromuscular Disorders, Journal of Immunological Methods, New Biotechnology, Journal of Translational Medicine
Any of a group of disorders associated with recurrent bacterial, fungal, protozoal, and viral infections and characterized by atrophy of the thymus gland, depressed cell-mediated immunity, and defective humoral immunity.
Related Journals of Cellular Immunodeficiencies:
Molecular and Cellular Biology, Cellular and Molecular Immunology, Cellular Immunology, The Journal of Pediatrics, Allergy, Asthma & Clinical Immunology, Blood, The Journal of Allergy and Clinical Immunology, Journal of Clinical Pathology, Cord Blood Stem Cells and Regenerative Medicine, Clinical Microbiology and Infection, BMC Genomics
Innate immune responses are those that rely on cells that require no additional training to do their jobs. These cells include neutrophils, monocytes, natural killer cells, basophils and mast cells and complement proteins. Innate responses to infection occur rapidly and reliably. Even small infants have excellent innate immune responses. When all these cells are unable to their job and cannot able to produce required immunity to the individual then the innate immunity disorder occurs.
Related Journals of Innate Immune Disorders:
Journal of Innate Immunity, Innate Immunity, Brain, Behavior, and Immunity, Frontiers in Immunology, Immunology, Trends in Immunology, Journal of Allergy and Clinical Immunology, Immunobiology, Veterinary Immunology and Immunopathology, Developmental & Comparative Immunology
Allergic asthma is the most common form of asthma. Mostly the symptoms of allergic and non-allergic asthma are the same. The allergic asthma is triggered by inhaling allergens. An allergen is a harmless substance such as dust mites, pet dander, pollen or mold. If a person is allergic to a substance, this allergen triggers a response starting in the immune system. Through a complex reaction, these allergens then cause the passages in the airways of the lungs to become inflamed and swollen. This results in coughing, wheezing and other asthma symptoms.
Related Journals of Allergic Asthma:
Current Allergy and Asthma Reports, Allergy, Asthma and Immunology Research, Journal of Asthma and Allergy, Annals of Allergy, Asthma and Immunology, Journal of Asthma, Allergy and Asthma Proceedings, Allergy, Asthma and Clinical Immunology, Iranian Journal of Allergy, Asthma and Immunology, International Immunopharmacology, Respiratory Medicine, Molecular Immunology
A disease caused by the deposition of antigen-antibody or antigen-antibody complement complexes on the surface of cells, resulting in the development of chronic or acute inflammation, which may be manifested by vasculitis, endocarditis, neuritis, or glomerulonephritis. Antigens bound to antibodies in immune complexes are normally cleared by various cellular mechanisms physiologically capable of eliminating even small quantities of ‘foreign’ antigens from circulation. Immune complex disease in humans is seen primarily in the setting of infection and in response to various therapeutic agents of protein or non-protein nature.
Related Journals of Immune Complex Diseases:
The Journal of Clinical Investigation, Annals of the Rheumatic Diseases, Journal of Investigative Dermatology, British Journal of Dermatology, Nature Immunology, Immunity, Clinical Biochemistry, Journal of Genetics and Genomics, BMC Medical Genetics, World Journal of Surgical Oncology, BMC Public Health
Multiple myeloma is also known as myeloma. It is a type of cancer that originates in the plasma cells of the bone marrow. These are protein-making cells which normally make different kinds of proteins that contain the antibodies of the immune system. In multiple myeloma, the plasma cells undergo what is referred to as a malignant transformation and thereby become cancerous. These myeloma cells stop making different protein in response to the immune system's needs and instead start to produce a single type of protein called monoclonal or M protein.
Related Journals of Multiple Myeloma:
Blood, International Journal of Basic & Clinical Pharmacology, Annals of Oncology, Clinical Lymphoma, Myeloma & Leukemia, The New England Journal of Medicine, Molecular Immunology, Cancer Letters, Clinical Lymphoma Myeloma and Leukemia, Academic Radiology, Blood Reviews, Pathologie Biologie
Severe acute respiratory syndrome (SARS) is a serious form of pneumonia. It is caused by a coronavirus (SARS-CoV) that was first identified in 2003. Infection with the SARS virus causes acute respiratory distress (severe breathing difficulty) and sometimes death. SARS was first reported in Asia in February 2003. The illness spread to more than two dozen countries in North America, South America, Europe, and Asia before the SARS global outbreak of 2003 was contained. Still there is no medication that is known to treat SARS. Treatment is supportive.
Related Journals of Severe acute respiratory syndrome:
Clinical Infectious Diseases, The Journal of Infectious Diseases, The New England Journal of Medicine, Virology Journal, Clinical Microbiology Reviews, American Journal of Roentgenology, Journal of Infection, Journal of Critical Care, Journal of Virological Methods, Clinical Microbiology and Infection Journal of the Formosan Medical Association
Severe Combined Immunodeficiency is a primary immune deficiency. The defining characteristic is usually a severe defect in both the T- & B-lymphocyte systems. This usually results in the onset of one or more serious infections within the first few months of life. There are at least 13 different genetic defects that can cause SCID. These defects lead to extreme susceptibility to very serious infections. The most common form of SCID is caused by a mutation in the SCIDX1 gene located on the X chromosome.
Related Journals of Severe Combined Immune Deficiency:
Journal of Clinical Pathology, Clinical and Experimental Immunology, Journal of American Medical Association, Journal of Clinical Pathology, Blood, The Application of Clinical Genetics, Orphanet Journal of Rare Diseases, The Journal of Allergy and Clinical Immunology, Clinical Immunology, Immunology and Allergy Clinics of North America
Hypogammaglobulinemia is a disorder that is caused by a lack of B-lymphocytes and a resulting low level of immunoglobulin (antibodies) in the blood. Immunoglobulin plays a dual role in the immune system by recognizing foreign antigens and triggering a biological response that culminates in the elimination of the antigen. Antibody deficiency is associated with recurrent infections with specific types of bacteria. In pure B-cell disorders, cellular immunity generally is intact and the frequency of viral, fungal, and mycobacterial (e.g. tuberculosis) infections is not increased. There are 5 major types of immunoglobulin: immunoglobulin G, immunoglobulin M (IgM), immunoglobulin A (IgA), immunoglobulin D (IgD), and immunoglobulin E (IgE).
Related Journals of Hypogammaglobulinemia:
International Journal of Infectious Diseases, Clinical Biochemistry, Journal of Autoimmunity, European Journal of Internal Medicine, Journal of Equine Veterinary Science, Journal of Infection Blood, The American Journal of Medicine, The Journal of Investigative Dermatology, Pediatria Polska, Current Allergy and Asthma Reports
Among the five classes of immunoglobulin: IgG, IgA, IgM, IgD, and IgE, IgG has the predominant role in protection against infection. Some patients have normal levels of immunoglobulin and all forms of IgG, but do not produce sufficient specific IgG antibodies that protect us from some viruses and bacteria. Patients who otherwise produce normal immunoglobulin levels but who lack the ability to produce protective IgG molecules against the types of organisms that cause upper and lower respiratory infections are said to have Specific Antibody Deficiency (SAD). SAD is sometimes termed partial antibody deficiency or impaired polysaccharide responsiveness. Specific IgG antibodies are important in fighting off infections; however, other components of our immune system also work to eradicate bacteria and viruses. T-cells complement proteins and IgA antibodies (to name a few) are parts of our immune system that work together during a complete immune response. If these other components work well, some patients with low specific antibody levels may rarely get sick. Antibodies of certain IgG subclasses interact readily with the complement system, while others interact poorly, if at all, with the complement proteins. Thus, an inability to produce antibodies of a specific subclass or mild deficiencies of other arms of the immune system may render the individual susceptible to certain kinds of infections but not others.
Related Journals of Specific Antibody Deficiency:
The Journal of Allergy and Clinical Immunology, Clinical & Experimental Immunology, European Journal of Internal Medicine, The American Journal of Medicine
Inflammatory abnormalities results in the body own immune system attacking the cells or tissues and may cause inflammation, which results in chronic pain, redness, swelling, stiffness, and damage to normal tissues.
Related Journals of Inflammatory Disorders:
Inflammation and Allergy - Drug Targets, Journal of Inflammation Research, Journal of Ophthalmic Inflammation and Infection, European Journal of Inflammation, Journal of Inflammation
Evolutionary immunology is the study of the evolution of immunity and the immune system over ages. It includes the study and historical development of the ability to recognize foreign antigenic material.
Related Journals of Evolutionary Immunology:
Trends in Immunology, Transplant Immunology, European Journal of Immunology, Clinical and Experimental Immunology, Advances in Immunology