International Publisher of Science, Technology and Medicine


Journal of Primary &
Acquired Immunodeficiency Research

Editorial Board: Jeffrey A. Frelinger, PhD
 University of Arizona, USA  view all
ISSN: 2324-853X
Frequency: Biannual
Formerly: Journal of Immunodeficiency & Disorders
Journal of Primary & Acquired Immunodeficiency Research (JPAIR) promotes rigorous research that makes a significant contribution in advancing knowledge on immunodeficiency and related diseases. JPAIR includes all major themes pertaining to primary and secondary immunodeficiency, their causative factors and their treatments.
Journal of Primary & Acquired Immunodeficiency Research is a subscription based journal that provides a range of options to purchase the articles and also permits unlimited Internet access to complete Journal content. It accepts commentaries, letter to editor, rapid/short communications, full/mini reviews and original research papers. Articles submitted by authors are evaluated by a group of peer review experts in the field that ensures the published articles to be of high quality, reflect solid scholarship in their fields, and that the information they contain is accurate and reliable.


Current Issue
Editors & Editorial Board Members  
J Immunodefic Disor 2013, 2:1   
Mast Cells as Reservoirs for HIV Latency   Editorial
Silvia Bulfone-Paus
J Immunodefic Disor 2013, 2:1    doi: 10.4172/2324-853X.1000e108

Mast Cells as Reservoirs for HIV Latency

More than a decade ago, Bannert and colleagues first reported that human mast cell (MC) progenitors are susceptible to infection with HIV-1. This finding was confirmed and extended by other groups in the following years providing in vivo evidence that tissue MCs, developing from infected human MC progenitors, remain productively infected in infected people. Moreover, evidence was shown that Toll-like receptor (TLR) 2, TLR4, or TLR9 stimulation of latently infected mast cells induced re-initiation of HIV-1 replication.

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Gene Therapy in Primary Immunodeficiencies   Review Article
Inês Rosinha, Laura Costa, Mara Pinto, Natália Barbosa and Patrícia Rosinha
J Immunodefic Disor 2013, 2:1    doi: 10.4172/2324-853X.1000103

Gene Therapy in Primary Immunodeficiencies

Primary immunodeficiencies (PIDs) result from inherited mutations in genes involved in the production, function or survival of specific elements of the immune system (T, B, NK lymphocytes, neutrophils, antigen-presenting cells). Knowing that these elements derive from pluripotent hematopoietic stem cells, it has been tried to use allogeneic hematopoietic stem cell transplantation (HSCT) as an alternative for patients with a PID, which has proven to be an effective  therapeutic approach leading to immune restoration.

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Non-Antibacterial Implications of Tetracyclines in the Management of Periodontitis: An Update   Research Article
Bangalore Varadhan Karthikeyan, Devireddy Venkata Tejaswi and Munivenkatappa Lakshmaiah Venkatesh Prabhuji
J Immunodefic Disor 2013, 2:1    doi: 10.4172/2324-853X.1000104

Non-Antibacterial Implications of Tetracyclines in the Management of Periodontitis: An Update

Recent research has shown that the majority of the soft and hard tissue destruction in periodontitis occurs due to activated host immuneinflammatory defence mechanisms in response to bacterial plaque. The importance of the host inflammatory response in periodontal pathogenesis presents opportunity for exploring new treatment strategies for periodontitis by means of host modulation. One of such treatment strategy is the use of drugs like Chemically Modified Tetracyclines, which are derivatives of tetracycline group of antibiotics, but lack antimicrobial action and have potent host modulating properties. The main advantage of Chemically Modified Tetracyclines over conventional tetracyclines is that they do not produce the side effects such as gastro-intestinal toxicity and antibiotic resistance.


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Effect of Different Hydatid Cyst Molecules on Hela and Vero Cell Lines Growth In vitro   Research Article
Nasir Aref, Hedayatollah Shirzad, Morteza Yousefi and Hossein Yousofi Darani
J Immunodefic Disor 2013, 2:1    doi: 10.4172/2324-853X.1000105

Mast Cells as Reservoirs for HIV Latency


Hydatid cyst is the larval stage of the tapeworm, Echinococcus granulosus, a parasite responsible for hydatid disease or hydatidosis in human and livestock. This disease considered as one of the most important cosmopolitan zoonotic infection with different mammalian hosts being involved in the life cycle. It has been shown that in a large retrospective study of patients with cancer, the prevalence of hydatid cyst was significantly lower than in normal subjects. Antitumor activity of some other parasites have also been demonstrated.

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