The Journal of Virology & Antiviral Research (JVA) promotes rigorous research that makes a significant contribution in advancing knowledge for Microbiology and Medicine. The journal includes all major themes pertaining to viral diseases and treatment.
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Prevalence of Hepatitis Virus and HBV/HCV Interactions in Opiate Addict Subjects
Aims of the study were: 1) the assessment of the prevalence of HBV, HCV and HDV infections in opiate addict subjects; 2) the study of the viral interaction in vivo. Method: The study evaluated HBV and HCV infections in 1682 subjects assisted from 1990 to 2010. Outcomes: In 2010 the prevalence of HBV infection was of 42.3%; the number of HBs Ag carrier subjects was of 4,4%. HCV infection prevalence rose of 60.4%. The prevalence of the co-infection HBV/HCV was of 32.0%; during the co-infection phase, HBV infection spread earlier with a 2.8 higher probability than HCV infection. The RNA of HCV virus was positive in 25.9% of the cases of HBsAg carrier subjects. The RNA of HCV resulted to be positive among HBV infected subjects compared to HBV carrier subjects with O.R. 10.47.
Herpes Simplex Virus Type-2 Infection and Associated Risk Factors among Weaver’s Community in Tamil Nadu State, India
Objective: To determine the presence of HSV-2 and its association to demographic and risk factors in the weavers population of Tamilnadu. Methods: 296 adults were surveyed in Kanchipuram, Erode and Tiruvannamalai districts of Tamil Nadu. Socio-demographic characteristics were obtained through interviews and 5 ml of blood was collected from individuals age 18 and over. Samples were tested for IgG anti HSV antibodies. The association between HSV- 2 infection and different behavioural variables was analysed using chi-square analysis.
“To Treat or Not to Treat?”: A Case of Severe Acute Hepatitis-B Treated with Entecavir Compared to a Case of Milder, Untreated Disease
Purpose: Acute hepatitis B, usually a benign disease in the immunocompetent adult, may be fatal in a minority of cases. The oral deoxyguanosine nucleoside analogue entecavir has gained a definite role in treating chronic hepatitis B virus infection. However, the indications and the specific timing for antiviral treatment in severe AHB remains to be established. We aimed at gaining insight into such indication based on clinical observation of two cases.