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Journal of Applied Bioinformatics & Computational BiologyISSN: 2329-9533

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Research Article, J Appl Bioinform Comput Biol Vol: 4 Issue: 2

A Computational Comparative study of α-Glucosidase Enzyme Divergence

Mohammad Hossein Mehraban1,2, Younes Ghasemi2 and Sadeq Vallian1*
1Division of Genetics, Department of Biology, Faculty of Science, University of Isfahan, Isfahan, IR Iran
2Department of Pharmaceutical Biotechnology, Faculty of Pharmacy and Pharmaceutical Sciences Research Centre, Shiraz University of Medical Sciences, Shiraz, IR Iran
Corresponding author : Dr. Sadeq Vallian
Division of genetics, Department of Biology, Faculty of Science, University of Isfahan, Isfahan, Iran,
Tel:983117932456
E-mail: [email protected]
Received: June 23, 2015 Accepted: August 07, 2015 Published: August 14 2015
Citation: Mehraban MH, Ghasemi Y, Vallian S (2015) A Computational Comparative study of a-Glucosidase enzyme Divergence. J Appl Bioinform Comput Biol 4:1. doi:10.4172/2329-9533.1000116

Abstract

A Computational Comparative study of α-Glucosidase enzyme Divergence

α-Glucosidase (α-Gls) enzymes have a crucial role in digestion of carbohydrates and biosynthesis of glycoproteins. Theses enzymes hydrolyze terminal glycosidic bonds and release α-glucose from the substrate chain. They are found in prokaryotic cells, plants and mammalian tissues such as liver, blood and especially intestine. The last step of carbohydrate digestion is catalyzed by α-glucosidases (namely maltase-glucoamylase or MGAM in mammals) which results in liberation of glucose.

Keywords: α-Glucosidase; Phylogenetic trees; Evolution; Multiple alignments

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