Journal of Otology & RhinologyISSN: 2324-8785

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Research Article, J Otol Rhinol Vol: 3 Issue: 6

A Pilot Study of Quantitative Measurements of Nasal Function in Rhinitis and the Therapeutic Effects of Botulinum Toxin

Andrew Blitzer1*, Dan Novakovic2, Scott M Rickert3 and Lesley F Childs4
1Professor Emeritus of Otolaryngology-Head and Neck Surgery, Columbia University College of Physicians and Surgeons, NYC, USA; Adjunct Professor of Neurology, Icahn School of Medicine, Mt. Sinai, USA ; Director, NY Center for Voice and Swallowing Disorders, NYC, USA
2Department of Otolaryngology/Head and Neck Surgery, University of Sydney,New South Wales, Australia
3Asst. Professor of Otolaryngology and Pediatrics, NYU Langone Medical Center,NYC, USA
4Asst Professor of Otolaryngology, UT Southwestern Medical Center, Dallas, Texas, USA
*Corresponding author : Andrew Blitzer
MD, DDS, 425 West 59th Street, New York, NY 10019
Tel: 212-262-9500
E-mail: [email protected]
Received: May 06, 2014 Accepted: September 10, 2014 Published: December 05, 2014
Citation: Blitzer A, Novakovic D, Rickert SM and Childs LF (2014) A Pilot Study of Quantitative Measurements of Nasal Function in Rhinitis and the Therapeutic Effects of Botulinum Toxin. J Otol Rhinol 3:6. doi:10.4172/2324-8785.1000195

Abstract

A Pilot Study of Quantitative Measurements of Nasal Function in Rhinitis and the Therapeutic Effects of Botulinum Toxin

Objective: Symptoms of rhinitis can be attributed to the stimulation of cholinergic nerve endings, which leads to mucosal hypersecretion and an increase in nasal blood flow. As botulinum toxin is a powerful cholinergic blocker, the application of this toxin intranasally may help to decrease the symptom complex associated with rhinitis. A pilot study was designed to evaluate the use of hot wire airflow, measurement of stimulated secretions, and the effect of botulinum toxin on both. A quantitative assessment of this use in humans has never been performed.

Study Design: Double-blind, placebo controlled randomized control trial.

Methods: Botulinum toxin was injected into the inferior turbinates of 8 human subjects. Patients were their own controls, with each side randomized to receive onabotulinumtoxinA (BTX-A) (four 2.5 unit aliquots) or equivalent volume of normal saline.. Airflow was measured at baseline and each visit using hot-wire airflow device. Baseline and stimulated nasal secretions were collected on filter paper then weighed. The patients were followed monthly for a total of 4 months.

Results: There was a statistically significantly greater airflow on the BTX-A treated sides compared with control sides at 4 months. There was also a statistically significant decrease in stimulated secretions at 3 months. There was a notable trend toward reduction of resting secretions and stimulated secretions in the BTX-A treated sides during the treatment period. There was also a trend toward greater airflow in the BTX-A treated sides during the treatment period.

Keywords: Botox; Botulinum toxin; Rhinitis; Nasal airflow; Level of Evidence: 1b

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