Journal of Vaccines & Clinical Trials.

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Radiation-Therapy Effects On Bone Hydroxyapatite Structure

Radiotherapy is associated with radiographically detected osteoporosis. The precise pathophysiology is not completely known yet. Hydroxyapatite (Hap, Ca₁₀(PO₄)₆(OH)₂) is the mineral component of the bone, and it can form chemical and mechanical bonds directly with living tissues, and with bone-implant interfaces as well. The aim of this research was to study the influence of external radiotherapy in the Hap ultrastructure. The experimental study was carried out on a section of bone from a human humerus, extracted from a male donor (50 years old). The bone tissue sample was irradiated with a telecobalt therapy equipment (Phoenix 2000), applying 35 fractions of 2 Gray each from Monday to Friday, until completing 70 Gray. The energy of the radiation and time of exposure used in this work was the same that it is used in common radiotherapy sessions. The calculations to determine the radiation dose were performed using the three-dimensional planner Eclipse 8.0 software. To evaluate the changes in the crystal structure of the Hydroxyapatite after each irradiation, an X-ray diffractogram was carried out on the bone sample using an X-ray diffractometer (Bruker D8) equipped with the copper anode (K-alpha=1.5406 A) and a detection scan of 5-80°. There are no differences between the diffractograms; thus, with the radiation-gamma, the same that it is used in common radiotherapy sessions, there are no appreciable changes in the crystal structure (ultrastructure) of Hap present in the bone. .eywords: .eywords: We concluded that there are no differences between the diffractograms for different exposure times.

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