Vector Biology Journal.ISSN: 2473-4810

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Alzheimer’s disease genetics, a multiplex model

Statement of the Problem: As an aging population alzheimer’s disease (AD) is a growing world-wide public health concern, with 13.9 million people expected to be living with dementia by 2060. Familial forms of AD follow a Mendelian inheritance, with heritability estimates (58-79%) showing a strong genetic component to sporadic AD. Multiplex Model: Over 40 genetic loci are associated with AD, and with polygenic risk profiling we are now able to correctly predict disease status around 80% of the time. Our analyses identify six biological pathways (immunity, endocytosis, cholesterol transport, ubiquitination, amyloid-β and tau processing) as pivotal in disease development. Epidemiological research also highlights a significant vascular component to AD development. The multiplex model assumes that changes to some, or all, of these model components act together to trigger a disease cascade, which ultimately results in the cell/synaptic loss observed in AD. AD could be triggered by a number of different patterns of deficits that may differ between tissues and over the course of disease development. Multi-omics approaches (Figure 1) allowed the identification of a gene-network enriched for both common and rare variants in AD. Conclusion & Significance: Genetic and environmental studies have changed our perception of AD, highlighting its multifactorial complexity. Application of genetic data to future research may include selection/enrichment for clinical trials and precision medicine, understanding of early disease development through risk related epidemiology, selective biomarkers and induced pluripotent stem cell models for single cell, multi-tissue/organoid and whole system chimeric analyses.

Special Features

Full Text

View

Track Your Manuscript

Recommended Conferences

Share This Page

Media Partners

Associations