Journal of Pharmaceutics & Drug Delivery Research ISSN: 2325-9604

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Carriers for Prodrug Synthesis

A prodrug could also be a medicine or compound that, after administration, is metabolized (i.e., converted within the body) into a pharmacologically active drug rather than administering a drug directly, a corresponding prodrug are often used to improve how the drug is absorbed, distributed, metabolized, and excreted (ADME).
Many herbal extracts historically utilized in medicine contain glycosides (sugar derivatives) of the active, which are hydrolyzed within the intestines to release the active and more bioavailable aglycone for instance, salicin could also be a β-D-glucopyranoside that's cleaved by esterases to release salicylic acid. Aspirin, aspirin, first made by Felix Hoffmann at Bayer in 1897, could also be an artificial prodrug of salicylic acid.
The first synthetic antimicrobial drug, arsphenamine, discovered in 1909 by Sahachiro Hata within the laboratory of Ehrlich, isn't toxic to bacteria until it has been converted to a lively form by the body. Likewise, prontosil, the first sulfa, must be cleaved within the body to release the active molecule, sulfanilamide. Since that time, many other examples are identified.

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