CAR-T Cell Therapy in Cancer: Revolutionizing Immunotherapy for Precision Medicine

Chimeric Antigen Receptor T-cell (CAR-T) therapy has emerged as a groundbreaking immunotherapeutic approach for treating hematologic malignancies and is being investigated for solid tumors. This innovative strategy involves engineering T cells to express synthetic receptors targeting specific tumor antigens, enabling precise tumor cell recognition and destruction. While CAR-T therapy has shown remarkable success in cancers like leukemia and lymphoma, challenges such as toxicity, antigen escape, and limited efficacy in solid tumors remain. This article explores the development, mechanisms, clinical applications, and challenges of CAR-T therapy, along with potential solutions and future directions. The integration of CAR-T therapy with other treatments could usher in a new era of personalized cancer care.