Clinical Oncology: Case Reports

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Kailash C. Chadha, PhD

Kailash C. Chadha, PhD

Editor In Chief

Department of Molecular and Cellular Biology
Roswell Park Cancer Institute, USA

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NLM ID:  101776340   Frequency: Monthly

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About the Journal


Clinical Oncology Case Reports is a peer-reviewed International clinical and medical oncology and cancer research Journal. Clinical Oncology Case Reports (COCR) is a high-impact multidisciplinary journal focus on the area of clinical and medical investigation.

Clinical Oncology: Case Reports Journal is essential reading for all those with an active interest in the treatment of cancer. Its multidisciplinary approach keeps readers up to date with the developments in their own as well as related fields. The Journal focuses on all types of malignant disease and therapy such as pathology, diagnosis, therapy including radiotherapy, and systemic treatment.

The Journal welcomes all cancer surgeons, radiation oncologists, medical oncologists, gynecologic oncologists, and pediatric oncologists. Each issue is carefully selected to provide a combination of high-quality original research, informative case reports, and state-of-the-art reviews. The Journal encompasses multi-dimensional research related to Chemotherapy, immunotherapy, tumor therapy, Radiation oncology, surgical oncology, Neoplasms, Radiotherapy, Biomarkers, Carcinogenesis,  and all other issues related to Oncology.

The journal accepts original and high-quality research and reviews on all aspects of oncology including carcinogenesis, metastasis, epidemiology, chemotherapy, and viral oncology as case reports. All articles are peer-reviewed and published under the guidance of our Editorial Board members.  

The Editorial Manager System helps in maintaining the quality of the peer review process and provides easy access to the authors to track the process of manuscript evaluation and publication in an automated way. All the submitted manuscripts undergo peer review by the subject matter experts under the supervision of the Editor-in-Chief or assigned Editorial committee member of the Journal of Clinical Oncology:  Case Reports. Approval of at least two independent reviewers and the editor is mandatory for the acceptance of the manuscript for publication.

Submit your manuscripts directly in the Editorial Tracking system: Online Submission System

  • Carcinogenesis
  • Lymphoma
  • Neoplasm
  • Chemotherapy
  • Immunotherapies
  • Radiation Oncology
  • Tumor Immunity
  • Liver Oncology
  • Cancer Therapy
  • Surgical Oncology
  • Chemotherapy
  • Anti-Cancer Drugs

Cancer Epidemiology

Malignancy is the uncontrolled development of unusual cells anyplace in a body. These unusual cells are termed disease cells, threatening cells, or tumor cells.

A few sorts of tumor keep running in specific families, yet most diseases are not plainly connected to the qualities we acquire from our guardians.

Diseases and the strange cells that form the malignancy tissue are further distinguished by the name of the tissue that the anomalous cells began.

Pancreatic Cancer

Pancreatic cancer instigates in the tissues of the pancreas - An organ in the abdomen that lies behind the lower part of the stomach. Pancreas releases enzymes that aid digestion and produces hormones that help and manage blood sugar. Numerous kinds of developments can happen in the pancreas, including cancerous and noncancerous tumors. The most common type of cancer that forms in the pancreas begins in the cells that line the ducts that carry digestive enzymes out of the pancreas.

Cancer Gene Therapy

Tumor Gene Therapy is the vital quality and cell treatment asset for disease specialists and clinicians, staying up with the latest with the most recent improvements in quality and cell treatments for growth. Immunotherapy, Cancer gene therapy and quality exchange. Immunotherapy utilizes hereditarily adjusted cells and viral particles to animate the resistant framework to devastate tumor cells. Late clinical trials of second and third era immunizations have demonstrated empowering results with an extensive variety of growths, including lung tumor, pancreatic disease, prostate malignancy and dangerous melanoma. Cancer Gene Therapy, which utilizes viral particles that repeat inside of the growth cell to bring about cell demise.


Cancer is a class of diseases characterized by out-of-control cell growth. There are over 100 different types of cancer, and each is classified by the type of cell that is initially affected. Cancer harms the body when altered cells divide uncontrollably to form lumps or masses of tissue called tumors (except in the case of leukemia where cancer prohibits normal blood function by abnormal cell division in the blood stream). Tumors can grow and interfere with the digestive, nervous, and circulatory systems, and they can release hormones that alter body function.

The study aims at clinical oncology and radiotherapy, as well as in radiotherapy physics, techniques and radiotherapy equipment. Case reports should include relevant positive and negative findings from history, examination and investigation, and can include clinical photographs, provided these are accompanied by written consent to publish from the patient(s). Case reports should include an up-to-date review of all previous cases in the field.

Radiation therapy is a type of cancer treatment that uses high doses of radiation to kill cancer cells and shrink tumors. Radiation therapy most often uses X-rays, but protons or other types of energy also can be used. The term "radiation therapy" most often refers to external beam radiation therapy. Radiation therapy or radiotherapy, often abbreviated RT, RTx, or XRT, is a therapy using ionizing radiation, generally as part of cancer treatment to control or kill malignant cells and normally delivered by a linear accelerator.

Anti Cancer Drugs

Anti-cancer drugs are also called anti-neoplastic agents or chemotherapeutic agents. They act upon rapidly dividing cancer cells and destroy them. They can be used alone (single-drug therapy) or several at once (combination therapy). Various kinds of anti-cancer drugs are alkylating agents (cisplatin, chlorambucil, procarbazine, carmustine etc.), antimetabolites (methotrexate, cytarabine, gemcitabine etc.), anti-microtubule agents (vinblastine,paclitaxel etc.), topoisomerase inhibitors (etoposide, doxorubicin etc.), cytotoxic agents (bleomycin, mitomycin etc.). They have severe adverse effects like hair loss, nausea and vomiting, anemia etc.


Chemotherapy (also called chemo) is a type of cancer treatment that uses drugs to kill cancer cells. Chemotherapy works by stopping or slowing the growth of cancer cells, which grow and divide quickly. Chemotherapy is used to:

Treat cancer: Chemotherapy can be used to cure cancer, lessen the chance it will return, or stop or slow its growth.

Ease cancer symptoms: Chemotherapy can be used to shrink tumors that are causing pain and other problems.

Targeted therapy

Targeted therapy is the foundation of precision medicine. It is a type of cancer treatment that targets proteins that control how cancer cells grow, divide, and spread.

Most targeted therapies are either small-molecule drugs or monoclonal antibodies.

Small-molecule drugs are small enough to enter cells easily, so they are used for targets that are inside cells.

Monoclonal antibodies, also known as therapeutic antibodies, are proteins produced in the lab. These proteins are designed to attach to specific targets found on cancer cells. Some monoclonal antibodies mark cancer cells so that they will be better seen and destroyed by the immune system. Other monoclonal antibodies directly stop cancer cells from growing or cause them to self-destruct. Still others carry toxins to cancer cells.

Hormone Therapy

Hormone therapy is a cancer treatment that slows or stops the growth of cancer that uses hormones to grow. Hormone therapy is also called hormonal therapy, hormone treatment, or endocrine therapy. Hormone therapy falls into two broad groups, those that block the body’s ability to produce hormones and those that interfere with how hormones behave in the body.

Gastrointestinal Oncology

Cancer is one of the world's leading causes of deaths, disorders and disabilities. Gastrointestinal tract cancer follows a peculiar distribution pattern across the globe among all organ cancers. More deaths than any other cancers are attributed to them. These malignant gastric tumors are also referred to as stomach cancer and are mainly found in people aged 50 to 70 years.

Gastrointestinal (GI) Cancer is a collective term which encompasses a group of growths of mass or cancer cells that affect the gastrointestinal tract and digestive system. These cancers develop through the formation of a lump or ulcer within the stomach and spread diffusely throughout the other parts of the stomach.


When the body’s immune system detects antigens, it produces antibodies. Antigens are harmful substances, such as bacteria, viruses, fungi, or parasites. Antibodies are proteins that fight infection. Monoclonal antibodies are made in a laboratory. When they are given to patients, they act like the antibodies the body produces naturally. A monoclonal antibody is directed against a specific protein in the cancer cells, and it does not affect the cells that do not have that protein. When a monoclonal antibody attaches to a cancer cell, they may accomplish the following goals:

  • Allow the immune system to destroy the cancer cell.
  • Prevent cancer cells from growing rapidly.
  • Deliver radiation directly to cancer cells.
  • Diagnose cancer.
  • Carry drugs directly to cancer cells.

Precision Medicine

Precision medicine is an approach to patient care that allows doctors to select treatments that are most likely to help patients based on a genetic understanding of their disease. This may also be called personalized medicine. The idea of precision medicine is not new, but recent advances in science and technology have helped speed up the pace of this area of research.

Stem cell transplants

Stem cell transplants are procedures that restore blood-forming stem cells in people who have had theirs destroyed by the very high doses of chemotherapy or radiation therapy that are used to treat certain cancers. Blood-forming stem cells are important because they grow into different types of blood cells. The main types of blood cells are:

White blood cells, which are part of your immune system and help your body fight infection; Red blood cells, which carry oxygen throughout your body; Platelets, which help the blood clot.


Carcinogenesis, also called oncogenesis or tumorigenesis, is the development of a cancer, whereby normal cells are converted into cancer cells. The development is characterized by changes at the cellular, genetic, and epigenetic levels and abnormal cell division. Cell division is a physiological manner that happens in nearly all tissues and below a variety of circumstances. Normally stability among between proliferation and programmed cell death, within the form of apoptosis, is maintained to ensure the integrity of tissues and organs.


Chemotherapy is a category of cancer treatment that makes use of one or extra anti-cancer drugs (chemotherapeutic agents) Chemotherapy can be given with a curative intent (which nearly constantly involves combos of medication), or it could aim to prolong life or to reduce signs and symptoms (palliative chemotherapy). Chemotherapy is one of the fundamental classes of the scientific discipline particularly committed to pharmacotherapy for most cancers, which is referred to as scientific oncology .

Immune checkpoint inhibitors enhance T cell response against malignant cells and are standard of care in many tumor types. Disinhibition of cytotoxic T cells in normal organs and inhibitrion of regulatory T cells can lead to immune-related adverse events. Immune Checkpoint Inhibitors (ICPIs) have revolutionized the field of oncology and have been shown to increase survival in many tumor types. ICPIs work by targeting molecules involved in downregulating the immune response, ultimately resulting in activation of cytotoxic T-cells and enhancing the immune system's ability to recognize and destroy neoplastic tissue.


Immunotherapy is the "treatment of ailment by using inducing, enhancing, or suppressing an immune reaction". Immunotherapies designed to elicit or expand an immune response are categorised as activation immunotherapies, at the same time as immunotherapies that lessen or suppress are categorised as suppression immunotherapies.

Liver Oncology

Liver cancer is the cancer that originates in the liver. Since liver is made up of different types of cells, several types of tumors may form there. Some of them may be benign and some are cancerous and can spread to other parts of the body. These tumors have different causes and are treated differently.


Cancer happens while there is an uncontrolled growth of extraordinary cells that thrive and spread rather than dying as they would inside the life cycle of a normal cell. Lymphoma is cancer that begins in the white blood cells or lymphocytes. Lymphatic cancers are categorised by the type of immune cells affected. There are two important types of Lymphatic cancers are Hodgkin and non-Hodgkin. Within those, there are many subtypes.


Neoplasm is an abnormal growth of tissue, which if it forms a mass, is commonly called a tumor. This abnormal growth (neoplasia) generally but no longer usually forms a mass. ICD-10 classifies neoplasms into four essential groups: benign neoplasms, in situ neoplasms, malignant neoplasms, and neoplasms of unsure or unknown behaviour. Malignant neoplasms are also virtually referred to as cancers and are the point of interest of oncology.

Radiation oncology

The area of radiation oncology covers the integration of radiation remedy into multimodal treatment approaches. Radiation Oncology gives an open access forum to discussion board for researchers and clinicians involved in the management and treatment of cancer patients, bringing collectively the contemporary studies and advances inside the field. Advances in treatment technology, in addition to advanced know-how of the underlying biological resistance mechanisms, will further strengthen the role of radiation oncology.

Tumor Immunity

The immune response to foreign antigens consists of humoral  and cellular mechanisms. Most of the humoral responses cannot prevent tumor growth. However, effector cells, such as T cells, macrophages, and natural killer cells, have relatively effective tumoricidal abilities.

Colorectal Cancer

Colon malignancy and tumor of the rectum can start as a little polyp, distinguishable through normal disease screening, for example, colonoscopy. Colon growth indications incorporate an adjustment in entrail propensities or dying. Colon malignancy and rectal tumor have numerous components in like manner. They are talked about together here aside from the area about treatment, where they are examined independently. Colorectal malignancy happens when tumors structure in the covering of the digestive organ. It is normal in both men and ladies. The danger of creating colorectal malignancy ascends after age 50.

Breast is made up of glands called lobules that can make milk and thin tubes called ducts that carry the milk from the lobules to the nipple. Breast tissue also contains fat and connective tissue, lymph nodes, and blood vessels.

Bosom tumor for the most part begins off in the inward covering of milk pipes or the lobules that supply them with milk. A harmful tumor can spread to different parts of the body.

The main indication of bosom growth regularly is a bosom protuberance or an anomalous mammogram. Bosom disease stages range from right on time, treatable bosom malignancy to metastatic bosom growth.


Cancer Therapy is an ever-increasing array of tools at the disposal of clinicians in their treatment of this disease. However, cancer is a tough opponent in this battle, and current treatments, which typically include radiotherapy, chemotherapy and surgery, are not often enough to rid the patient of his or her cancer. Cancer cells can become resistant to the treatments directed at them, and overcoming this drug resistance is an important research focus.

Carcinoma Case Reports

Carcinoma is a type of cancer that develops from epithelial cells. Specifically, a carcinoma is a cancer that begins in a tissue that lines the inner or outer surfaces of the body, and that generally arises from cells originating in the endodermal or ectodermal germ layer during embryogenesis. Case reports should include relevant positive and negative findings from history, examination and investigation, and can include clinical photographs, provided these are accompanied by written consent to publish from the patient.

Fast Editorial Execution and Review Process (FEE-Review Process):
Clinical Oncology: Case Reports is participating in the Fast Editorial Execution and Review Process (FEE-Review Process) with an additional prepayment of $99 apart from the regular article processing fee. Fast Editorial Execution and Review Process is a special service for the article that enables it to get a faster response in the pre-review stage from the handling editor as well as a review from the reviewer. An author can get a faster response of pre-review maximum in 3 days since submission, and a review process by the reviewer maximum in 5 days, followed by revision/publication in 2 days. If the article gets notified for revision by the handling editor, then it will take another 5 days for external review by the previous reviewer or alternative reviewer.

Acceptance of manuscripts is driven entirely by handling editorial team considerations and independent peer-review, ensuring the highest standards are maintained no matter the route to regular peer-reviewed publication or a fast editorial review process. The handling editor and the article contributor are responsible for adhering to scientific standards. The article FEE-Review process of $99 will not be refunded even if the article is rejected or withdrawn for publication.

The corresponding author or institution/organization is responsible for making the manuscript FEE-Review Process payment. The additional FEE-Review Process payment covers the fast review processing and quick editorial decisions, and regular article publication covers the preparation in various formats for online publication, securing full-text inclusion in a number of permanent archives like HTML, XML, and PDF, and feeding to different indexing agencies.


Articles published in Clinical Oncology: Case Reports have been cited by esteemed scholars and scientists all around the world. Clinical Oncology: Case Reports has got h-index 8 , which means every article in Clinical Oncology: Case Reports has got 8 average citations.

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