Clinical Experience Beyond Clinical Data on Breast Cancer – Case Report

This case report presents the clinical history, treatment, and response of a 59-year-old female patient diagnosed with metastatic breast cancer. The patient exhibited a delayed diagnosis due to refusal of a biopsy, leading to an advanced stage of the disease. Initial evaluation revealed a voluminous malignant breast tumor with axillary adenopathies and liver metastases. First-line therapy consisting of ribociclib and letrozole was initiated, resulting in a positive response with significant reductions in tumor size, complete remission of liver lesions, and improvement in overall well-being. The combination of ribociclib and letrozole demonstrated effectiveness and manageable toxicities in treating hormone receptor-positive, HER2-negative metastatic breast cancer.