Journal of Genes and Proteins-

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Comparison of the Hypoproteinemic Capacities of Erythropoietin and U-74389G

Aim: This study compared the hypoproteinemic effects of erythropoietin (Epo) and antioxidant drug U-74389G based on 2 preliminary studies. The provided results at serum total protein (TP) levels decline were co-evaluated in a hypoxia reoxygenation protocol of an animal model.

Materials and methods: TP levels were evaluated at the 60th reoxygenation min (for groups A, C and E) and at the 120th reoxygenation min (for groups B, D and F) in 60 rats. Groups A and B received no drugs, rats from groups C and D were administered with Epo; whereas rats from groups E and F were administered with U-74389G.

Results: The first preliminary study recommended a hypoproteinemic effect of Epo (p-value=0.4430). The second preliminary study proved the hypoproteinemic effect of U-74389G (p-value=0.0005). These 2 studies were co-evaluated since they came from the same experimental setting. The outcome of the co-evaluation was that U-74389G has at least 4-fold hypoproteinemic action than Epo (p-value=0.0000).

Conclusions: The neurologist must take into consideration the powerful hypoproteinemic effect of the 2 drugs; mainly that of U-74389G whether implicated in neurological diseases.

Special Features

Full Text


Track Your Manuscript

Media Partners