Journal of Pharmaceutics & Drug Delivery Research ISSN: 2325-9604

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Development of Extruded Starch Based Formulations Aimed for Local Drug Delivery to Oral Cavity

Development of Extruded Starch Based Formulations Aimed for Local Drug Delivery to Oral Cavity

The suitability of different starches as a basic substance for a prolonged release oral dosage form was evaluated. Starches were extruded slightly above gelatinization temperature. The shape of the melt was predetermined by a slot nozzle. Circular, tablet like single dosage forms were produced by manual die-cutting of the still elastic strands. Five different starches were used as basic substances: corn starch, pea starch, potato starch, high-amylose corn starch Eurylon®5 and amylose-free corn starch Waxilys®200. Menthol and clove oil were used as active ingredients. Physical characteristics were analyzed to prove storage stability of the products.

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