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Drug design

Journal of Pharmaceutics & Drug Delivery Research .ISSN: 2325-9604

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Drug design

Drug design, often mentioned as rational drug design or just rational design, is that the inventive process of finding new medications supported the knowledge of a biological target. The drug is most ordinarily an organic small molecule that activates or inhibits the function of a biomolecule like a protein, which successively leads to a therapeutic benefit to the patient. In the most elementary sense, drug design involves the planning of molecules that are complementary in shape and charge to the bio molecular target with which they interact and thus will bind to it. Drug design frequently but not necessarily relies on computer modelling techniques.
The phrase "drug design" is to some extent a misnomer. A more accurate term is ligand design (i.e., design of a molecule which will bind tightly to its target). Although design techniques for prediction of binding affinity are reasonably successful, there are many other properties, like bioavailability, metabolic half-life, side effects, etc., that first must be optimized before a ligand can become a secure and efficacious drug.
The phrase "drug

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