Effects of microgravity on human induced pluripotent stem cell derived cardiomyocytes: A comprehensive review
For the future of regenerative medicine era, the efficient generation of cardiomyocytes from human pluripotent stem cells (hiPSC- CM) is very critical. Some extreme environment like microgravity and 3D culture can profoundly modulate cell proliferation and survival in efficient manner. The International Space Station (ISS) becoming commonplace for utilizing the space environment for better understanding the risks and benefits of human space flight along with role of extreme environment on cellular level. This comprehensive review literature includes some modern studies on effect of microgravity on cellular and genetic level of cardiomyocyte. Human instigated pluripotent immature microorganism inferred cardiomyocytes (hiPSC-CMs) were used to consider the impacts of microgravity on cell-level heart capacity and quality articulation. The hiPSC-CMs were refined on board in the ISS for 5.5 weeks and their quality articulation, structure, and capacities were contrasted and control hiPSC-CMs in standard gravity. Presentation to microgravity on the ISS modifies the hiPSC-CM calcium dealing with limit where the RNA-sequencing examination exhibited that 2,635 qualities were differentially communicated among flight, post-flight, and ground control tests, incorporating qualities associated with mitochondrial digestion.