GET THE APP

Elucidating the bone developmental defect in Werner Syndrome using stem cells

Advanced Biomedical Research and Innovation.

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Elucidating the bone developmental defect in Werner Syndrome using stem cells

Werner Syndrome (WS) is an autosomal recessive genetic disorder characterized by premature aging. This disease is caused by mutations in the WRN gene. The first sign of WS is short stature. Individuals with WS have an abnormally slow growth rate, and growth stops at puberty. As a result, affected individuals have short stature. However, the mechanism is still not clear. To find out the cause of short stature in WS, the author reprogrammed the WS patients’ fibroblasts and the isogenic normal control into mesenchymal stem cells and compared the transcriptome by RNA-Seq.

Special Features

Full Text

View

Track Your Manuscript

Media Partners

Associations