Medical Microbiology Reports

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Genetic and Environmental Factors Influencing Embryological Errors lead to congenital alformations: Search for possible improvements

In the entire biological world including microorganisms, it is the female strain/ female sex, which has been bestowed exclusive responsibility by
the evolutionary plasticity for “conceiving” (becoming diploid by way of gemetes) and later nurturing the developing embryonal stages until the
birth of next generation offspring. In this evolutionary compulsion, though genetically, both male and female ”parent” contribute almost equally
(50:50 for nuclear genes ; but female gamete may have extra cytoplasmic genes in mammals), but the female parent has to depend on external
environment, dietary intake and several harmful exposures. Therefore, embryological developments are terribly prone to lot many environmental
factors besides being dependent on gene combinations in the developing foetus for thousands of traits shaping within an individual, to be born.
The developmental defects or malformations simply mean “traits present at birth”, which in turn are again two types; external malformations or
developmental errors ( features) which we can immediately see and the internal congenital malformations which we cannot immediately see.
The new generation individual has two phases, gross features which we can see or, are External and, Internal traits or organs which we cannot
see. Considering situations in our species, we are more than selfish in improving over hundreds of malformations and or developmental errors.
Congenital anomalies in general populations will be presented on the following order with comments on their possible aetiology; role of genetic
factors and role of environmental factors.(A) Simple anatomical errors : Digital errors in palms and soles Polydactyly, Internal:- Crossed Renal
ectopia; (B) Major orthopaedic anomalies involving skull, limbs etc; (C) Inborn errors of metabolism influencing congenital defects and internal
developmental errors. Citing examples on published work, this presentation will focus on some very important and most relevant suggestions
regarding : change in dietary or eating habits (consumption of addictive drugs) , adaptive attitudes towards herbal medicines and strict avoidance
of consanguineous marriages.

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