Implementation of a tool in the management of the follow up of cancerous in the university hospital establishment of ORAN (UHEO) in Algeria
Introduction: The success of therapeutic control of tumor process
depends on their early diagnosis. It is therefore necessary to develop
reliable and simple methods for identifying tumors in the early stages
of evolution. This application was the basis for the development of
tumor markers. It requires an accurate determination of serum levels
of the marker at all levels. Its use in daily practice still requires a
computer system capable of integrating clinical and therapeutic data,
allowing a graphical representation of the kinetics and calculates the
various kinetic parameters.
Aim: The aim of this work is to demonstrate the value of the kinetic
in valuating the therapeutic efficacy of anti-cancer and optimize
the management of patients with different cancers at the University
Hospital of Oran in Algeria.
Methodology: The kinetics software is not available, the software “CHTM
KenitecTM” was developed at the Pharmacovigilance department
of the UHEO. This software allows the graphical representation of the
kinetics of tumor markers (CA 125, CA19.9, CA 15-3, PSA, CEA, AFP,
HCG, etc.) as well as calculation and tracking of pharmacokinetic
parameters (half time apparent life, nadir and doubling time).
Results: In total, we received 23 patients, 17 women and 6 men
ranging in age between 37 and 77 years, with an average of 57 years;
and carriers of different cancers i.e., 8 Patients with breast cancer, 4
have ovarian cancer and 11 patients suffering from gastrointestinal
cancers including 6, in total, at the stage of metastasis (liver, lung, bone
Conclusion: By increasing the specificity of the exploration
cancer, tumor markers provide better prescription of radiological
examinations provided for a reliable discrimination threshold for the
diagnosis and the detection of metastatic disease.