Interplay Between Cardiovascular Diseases and Cancer: A Complex Interconnection

The intersection of Cardiovascular Diseases (CVDs) and cancer represents a critical frontier in medical research and clinical care. Both conditions share common risk factors, such as aging, lifestyle habits, and genetic predispositions, creating a bidirectional link. Cancer therapies, including chemotherapy, radiation, and targeted treatments, often result in cardiovascular complications, while pre-existing CVDs can influence cancer prognosis. This review explores the shared pathophysiological mechanisms, including inflammation, oxidative stress, and endothelial dysfunction, that underpin this interplay. Additionally, we examine strategies for early detection, management, and prevention of cardiotoxicity and provide insights into the emerging field of cardio-oncology. Understanding this complex relationship is essential for improving patient outcomes in an era of multimorbidity.