Clinical Oncology: Case Reports

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Isochromosome i(9)(q10): A Rare Chromosomal Aberration in B-cell Acute Lymphoblastic Leukemia

Cytogenetic analysis in Acute Lymphoblastic Leukemia (ALL) reveals number of non-random chromosome abnormalities which play an important role in prognostication of patients. Isochromosomes are uncommonnon-random chromosome aberrations in acute lymphoblastic leukemia (ALL) and prognostic significance of the presence of isochromosome(s) remains to be well established. The incidence of i(9q) in ALL is very low. Majority of the patients are older than 10 years and the aberration occurs in combination with other chromosomal abnormalities. We present two cases of adult BALL with i(9q) as one of the cytogenetic aberration at diagnosis. Case 1 patient was given standard treatment protocol and complete remission was achieved at the end of induction phase II therapy andCase 2 was a newly diagnosed case and was planned for standard BFM 90 chemotherapy. Theearly remissionis indicative of a favorable outcome in such cases.

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