Neurodevelopmental Screening Outcome of Saudi Infants with Hypoxic-ischemic Encephalopathy at Age of Twelve Months Using Bayley Infant Neurodevelopmental Screener
Objective: The study’s primary aim is to evaluate the
neurodevelopmental outcomes of infants with Hypoxic Ischemic
Encephalopathy (HIE), assessed at the age of 12 months by
Bayley Infants Neurodevelopmental Screener (BINS). The
secondary outcome is to examine the possible association between
abnormalities on brain Magnetic Resonance Imaging (MRI) and the
scores on BINS.
Design: retrospective analysis of prospectively collected data.
Setting: the neonatal follow up program at King Khalid university
hospital. Subjects: All inborn infants, who were born between
2014 to 2018, with moderate to severe HIE and managed with
Therapeutic Hypothermia (TH).
Interventions: BINS assessment at the age of 12 months. Main
outcome measures: comparisons between survivors and nonsurvivors based on BINS scores, and examination of potential
association of hypoxic ischemic changes in MRI studies with the
results of BINS.
Results: 48 infants received the diagnosis of moderate to severe
HIE; 8 of them (17%) expired before discharge. 16 infants (40%)
have completed the study assessment; of them, 62% were at
low risk for future neurodevelopmental delay, and 38% were at
moderate to high risk for future neurodevelopmental delay. Hypoxic
ischemic changes observed on MRI studies were found in 33.3%
of patients with moderate to high-risk BINS scores, and in 20% of
patients with low-risk scores.