New Ways to Design Vaccines: Nanodelivery, Cancer Vaccines and Systems Biology
Nanomaterials with defined physico-biochemical properties are versatile drug delivery platforms that may address the key technical challenges facing cancer vaccines and immunotherapy. They are typically made from natural or synthetic materials. Nanoparticles could enable a targeted delivery of tumor antigens and therapeutics and amplify immune activation via the use of new stimuli-responsive or immunostimulatory materials. I will point out here and briefly review the current state-of-the-art in nanoparticle-based strategies designed to potentiate cancer immunotherapies, including cancer vaccines with subunit antigens (e.g., oncoproteins, DNA and mRNA antigens) and whole-cell tumor antigens, dendritic cell-based vaccines, and immunotherapeutics based on cell death immune checkpoint blockade.