Journal of Pharmaceutical Sciences & Emerging Drugs ISSN: 2380-9477

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Oral administration of amphotericin B nanoparticles: Antifungal activity, bioavailability and toxicity in rats

The novel AMB formulations showed minimal toxicity and better efficacy compared to Fungizone_. No nephrotoxicity in rats was detected after a week of multiple dosing of AMB NPs based on BUN and PCr, which remained at normal levels. An oral delivery system of AMB-loaded to PLGA-PEG NPs with better efficacy and minimal toxicity was formulated.

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