Pathogenic and Preventive Role of MAIT Cells in Chronic Diseases

Background: Chronic disease encompasses a wide range of metabolic abnormalities. These factors largely account for this emerging interest and are notably marked by inflammation that implicates the immune system. MAIT (Mucosal-Associated Invariant T) cell expression is linked to chronic diseases.

Scope of the review: The current study reviews the MAIT cells role in metabolic pathologies in human chronic diseases like diabetes, asthma, and cancer.

Conclusion: MAIT cells are influenced by severe concepts, different expressions with a frequency reduction, and a protective to deleterious from phenotype shift, including chronic viral infections, autoimmune, and inflammatory conditions. The MAIT cells can play a pathogenic role by sustaining inflammation and cytotoxicity and physiological and pathological situations which may lead us to novel therapeutic approaches.