The Corpus Luteum, A Source and Target of Androgen

Normal physiological levels of androgens are important for female reproductive health. However, high levels of androgens, as seen in women with Polycystic Ovarian Syndrome (PCOS) (8%-13% of reproductive age women) [1] or gestational diabetes (incidence in US of 10%) [2] are associated with reproductive complications. Pathologies accompanying significantly elevated testosterone levels involve impaired ovulation and early pregnancy maintenance. Formation of the Corpus Luteum (CL) requires a normal ovulation process to occur. The CL plays a central role in the establishment and early maintenance of a pregnancy. Here we present a brief report on the function of the CL and our current understanding on the potential role and function of testosterone and the activated androgen receptor.