Endocrinology & Diabetes ResearchISSN: 2470-7570

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Editorial, J Metabonomics Metabolites Vol: 1 Issue: 1

An Unbiased Approach to Discover Novel Therapies for Liver Disease

Colleen Croniger*
Department of Nutrition, Case Western Reserve University, Cleveland Ohio 44107, USA
Corresponding author : Colleen Croniger, PhD
Department of Nutrition, Case Western Reserve University, Cleveland Ohio 44107, USA
Tel: +1-216-368-4967; Fax: +1-216-368-6644
E-mail: [email protected]
Received: June 12, 2012 Accepted: June 13, 2012 Published: June 15, 2012
Citation: Croniger C (2012) An Unbiased Approach to Discover Novel Therapies for Liver Disease. J Metabonomics Metabolites 1:1. doi:10.4172/2325-9736.1000e101

Abstract

An Unbiased Approach to Discover Novel Therapies for Liver Disease

Alcoholic liver disease (ALD) represents a range of clinical and morphological changes that range from  steatosis to inflammation and necrosis (alcoholic hepatitis) to progressive fibrosis (alcoholic cirrhosis). Most chronic heavy drinkers exhibit steatosis characterized by greater amount of macrovesicular fat content than microvesicular fat. In addition hepatocyte ballooning degeneration with mixed lobular inflammation is evident.

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