2 Author

Research Article Open Access

Computational Profiling of the Interaction Between Prion and SOD1

Author(s):

Eden Yitna Teferedegn1,2*, Batuhan Yesilyurt2 and Cemal Un2

Prion and SOD1 are implicated in a number of cascades of cellular reactions. Though prion is presumed to have multiple cellular functions, the absence of a crystallized form of mutant prion protein and the challenge in finding therapeutic options intimidates the scientific community from disseminating absolute picture of prion protein and prion diseases pathomechanism. In the same way, SOD1 is a critical protein that involves in a many cellular functions. SOD1 is mainly known for its active role in cellular oxidative stress. Superoxide dismutase activity, metal and protein binding and free radical detoxification are of well characterized activities of SOD1 . Both proteins are highly expressed in brain regions specifically in frontal cortex (BA9), Cerebellar hemisphere, NA (Basal ganglia... view more»

Abstract HTML PDF