Advanced Biomedical Research and Innovation

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Alain Chapel Author

AlainChapel@gmail.com

Subjects of specialization
Arthritic conditions, Bursa inflammation (Bursitis), Fibrositis (Fibromyalgia syndrome), Fractures, Kyphosis

Affiliation
University of Petra-Amman, Jordan,University of Jordan

Biography

Alain Chapel has been developing gene and cell therapy using non-human primates, immune-tolerant mice and rats to protect against the side effects of radiation. He collaborates with clinicians to develop strategies for treatment of patients after radiotherapy overexposures. He has participated in the first establishment of proof of concept of the therapeutic efficacy of mesenchymal stem cells (MSCs) for the treatment of hematopoietic deficit, radiodermatitis and over dosages of radiotherapy. 

Publications

Short Communication Open Access

Cell therapy since the allograft to universal transplant. How to transform a concept in a clinical trial : application in the treatment of the side effects of radiotherapy

Author(s): Alain Chapel

Cell therapy was demonstrated of main importance in the management of normal tissue radiation damage. Preclinical and clinical trial data suggest that mesenchymal stem cells (MSCs) are a practical and safe source of cells for stem cell-based therapies of severe tissue damage consecutive to radiation overexposure. MSCs were shown to migrate to damaged tissues supporting wound healing through a “cell drug” mode of action restoring skin and gut functions after irradiation. However, technical limits associated with large-scale ex vivo expansion indicate that alternative source is required to obtain sufficient cell numbers of the appropriate lineage to treat patients with severe disease.Based on this pluripotency and unlimited expansion potential, induced pluripotent stem cells (iPS... view more»

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