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Alejandra Vargas Valderrama Author
Subjects of specialization
Affiliation
Applied Microbiology, Applied Microscopy, Applied Mycology, Applied Physiology, Biomedical Research
INSERM U1197, University of Paris Saclay, France
Biography
Alejandra Vargas Valderrama is currently a 4th year PhD student from the University Paris Sud at the laboratory INSERM U1197 leaded by Dr Georges Uzan. Her main research project, supervised by Dr Mitjavila Garcia and Dr Guenou, focuses on the differentiation of hPSC into endothelial cells via a hemangioblast. Thanks to her PhD project, she participated in the iLite (innovations in Liver tissue engineering) project aiming to create an external bio-artificial liver. Her main research areas of interests are related to endothelial development and tissue engineering for the production of external vascularized tissues.
Publications
Short Communication Open Access
Generation of a bi-potent hemangiogenic progenitor from human pluripotent stem cells
Author(s): Alejandra Vargas Valderrama, Denis Clay, Georges Uzan, Hind Guenou and Maria Teresa Mitjavila Garcia
The close temporal-spatial relationship between hematopoietic and endothelial cells during early embryonic development has led to the hypothesis of a common ancestor, the hemangioblast. Here human pluripotent stem cells (hPSCs) endothelial and hematopoietic differentiation via a bipotent progenitor and an in vitro equivalent of the hemangioblast were explored. hPSCs were differentiated into hemangiogenic mesoderm through embryoid body (EB) formation under serum-free culture conditions. After three, five days of differentiation, a population positive for CD309 (VEGFR-2), CD144 (VE-Cadherin), CD143 (ACE) and CD34 was isolated based on the expression of CD144 and cultured either under endothelial or hematopoietic conditions.
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