Journal of Pharmaceutics & Drug Delivery ResearchISSN: 2325-9604

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Alexander RT Author

Alexander@RT.cn

Subjects of specialization
Post-traumatic stress

Affiliation
Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada

Biography

My name is  Alexander RT Cell Biology Program, I am from   The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada    My area of interests are   Post-traumatic stress                                         

Publications

Short Article Subscription

A Validated RP-HPLC Method for the Simultaneous Determination of Six High-Boiling Residual Solvents in Drug Substances and Its Implementation in Apis

Author(s):

Gangrade MG, Deshpande NM, Gharat HP*, More SD, Shinde SS, Raval VK, Sapre JV and Alexander RT

A new method using high-performance liquid chromatography coupled with ultra violet detection was developed and validated for the simultaneous quantification of six high-boiling residual solvents-Acetic acid, N,N-dimethylformamide, Dimethyl sulfoxide, N, N-dimethylacetamide, N-methyl-2-pyrrolidone and Benzyl alcohol in drug substances. This paper describes the development and validation of a simple and efficient RP-HPLC method for the determination of these high boiling residual solvents. Quantitation limits for Acetic Acid is 1000ppm (1000 μg/g of API), for Dimethylsulfoxide is 400 ppm (400 μg/g of API), for N, N dimethylformamide is 70 ppm (70 μg/g of API), for Dimethylacetamide is 80 ppm (80 μg/g of API), for N-methyl-2-pyrrolidone is 40 ppm (... view more»

DOI: 10.4172/2325-9604.1000173

Abstract HTML PDF

Google Scholars / Researchers Sites

Explore SciTechnol

GET THE APP