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Hindi Journal of Applied Bioinformatics & Computational BiologyISSN: 2329-9533
Amlan Chakraborty Author
Subjects of specialization
Affiliation
Pulmonary Immunology, Nanomedicine, Respiratory Diseases, Biotechnology
Amity Institute of Biotechnology, Amity University, Noida, India
Biography
Amlan Chakraborty has received his Ph.d in Immunology and Chemical Engineering and he has done MTech in Biotechnology and he done his research from Fibrosis Laboratory. He is the recipient of DST BOYSCAST and he received fellowship award in Engineering Science in 2011, Indian National Science Academy (INSA) Visiting fellow ship award in 2017.
Publications
Research Article Subscription
Natural Versus Synthetic Inhibition of the PI3K Pathway Causing Over-Expression and Reduced Apoptosis to HER2 Leading to ER+/HER2+ Breast Cancer
Author(s): Amlan Chakraborty, Apoorv Gupta and Pranav Patni
Natural Versus Synthetic Inhibition of the PI3K Pathway Causing Over-Expression and Reduced Apoptosis to HER2 Leading to ER+/HER2+ Breast Cancer
Amplification or over-expression of the HER2 gene occurs in approximately 30% of breast cancers. HER2 proteins have been shown to form clusters in cell membranes that may play a role in tumorigenesis. It has been found that patients with ER+ (Estrogen receptor positive)/HER2+ compared with ER-/HER2+ breast cancers may actually benefit more from drugs that inhibit the PI3K/AKT molecular pathway. The PI3K/AKT/mTOR pathway is an intracellular signalling pathway important in apoptosis and hence cancer. In case of ER+/HER2+ breast cancer thi... view more»
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