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Hindi Clinical Oncology: Case Reports
Amy L Mumbower andDaruka Mahadevan Author
Subjects of specialization
Affiliation
cancer, cancer oncology, Carcinogenesis, Hematology , Medical Oncology
Mays Cancer Center, MD Anderson Cancer Center, Institute for Drug Development, University of Texas Health San Antonio, United States
Biography
Dr. Daruka Mahadevan is working as scientist and professor at Mays Cancer Center, MD Anderson Cancer Center, Institute for Drug Development, University of Texas Health San Antonio, 7979 Wurzbach R, 3rd FL Zeller Bldg Z300 Drs Area, San Antonio, TX, 78229, United States. The author has specalization in cancer, cancer oncology, chemotherapy, Carcinogenesis, Chemotherapy
Publications
Case Report Subscription
Metastatic Thymic Carcinoma with novel KIT mutations masquerading as a Carcinoma of Unknown Primary Site
Author(s): Gabriel Roman Souza, Sarah Hackman, Kayla E Chamberlin, Dmytro Kovalskyy, Amy L Mumbower and Daruka Mahadevan
A patient diagnosed with thymic carcinoma was found to have three KIT mutations (F522C, V560del, and Y823S), two of them not previously documented. In addition, this is the first reported case of thymic carcinoma with more than one pathogenic KIT mutation. He was initially treated with imatinib mesylate (IM) with a minor response. Subsequently, IM was discontinued, and he was treated with cisplatin plus gemcitabine with clinical and radiologic response. A repeat liquid biopsy showed total suppression of V560del, Y823S, F522C, and KRAS amplification.
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