Antonio Martin Author

Review Article Open Access

Possible Role of the Transglutaminase-Catalyzed Reactions in the Pathogenesis of Neurodegenerative Diseases

Author(s):

Martina Iannaccone, Federica Titta, Fabiana Marra, Antonio Martin, Giulia De Vivo and Vittorio Gentile

Possible Role of the Transglutaminase-Catalyzed Reactions in the Pathogenesis of Neurodegenerative Diseases

Transglutaminases are ubiquitous enzymes which catalyze posttranslational modifications of proteins. The main activity of these enzymes is the cross-linking of glutaminyl residues of a protein/ peptide substrate to lysyl residues of a protein/peptide co-substrate. In addition to lysyl residues, other second nucleophilic cosubstrates may include monoamines or polyamines (to form monoor bi-substituted/crosslinked adducts) or –OH groups (to form ester linkages). In absence of co-substrates, the nucleophile may be wat... view more»

DOI: 10.4172/lpma.1000137

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