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Hindi La Prensa MedicaISSN: 0032-745X
Bassim I Mohammad Author
Subjects of specialization
Affiliation
Zileuton, Leukotriene inhibitors MK-886, Doxorubicin (DX)-induced acute kidney damage, Urea
College of Pharmacy, University of Al-Qadisiyah, Iraq
Biography
Bassim I Mohammad, belonging to College of Pharmacy, interested in the field of Leukotriene inhibitors MK-886; Zileuton; Doxorubicin (DX)-induced acute kidney damage; Dysfunctional kidneys; Creatinine; Urea; Acute renal failure ?from University of Al-Qadisiyah, Iraq
Publications
Research Article Open Access
A Comparative Study to illustrate the Effects of Beta-1 Adrenergic Receptor Allelic Polymorphism on Disease Outcome in Iraqi Patients with Acute Coronary Syndrome (on Metoprolol Therapy)
Author(s): Asma A Swadi, Bassim I Mohammad, Najah R Hadi and Hayder Al-Aubaidy
Objective: The response to metoprolol therapy in patients with acute coronary syndrome (ACS) is variable and a substantial element of this variability is linked to variation in CYP2D6 enzyme and adrenoreceptor (ADRB1) alleles, genotype polymorphism, affecting the phenotype in terms of both rate of metabolism of the active metoprolol (and hence its metabolic ratio) and the responsiveness of ADRB1 receptors to bound metoprolol. This study aims to investigate different clinically relevant allele variants (allele frequencies) of ADRB1 genes: (Arg389Gly: Gly/Gly, Gly/Arg, Arg/Gly) and to determine whether a specific genotype of Beta-1 adrenergic receptor genes (based on genetic polymorphism "allelic types" and combination) have impact on metoprolol effectiveness (clinical outcome) in Arabic ... view more»
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