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Hindi Clinical Oncology: Case Reports
Benita Wolf Author
Subjects of specialization
Affiliation
cancer, cancer oncology, Carcinogenesis
Medical Oncology Service, Department of Oncology, Lausanne University Hospital and University of Lausanne, Switzerland
Biography
Dr. Benita Wolf is working as scientist and professor at Medical Oncology Service, Department of Oncology, Lausanne University Hospital and University of Lausanne, Switzerland. The author has specalization in cancer, cancer oncology, chemotherapy, Carcinogenesis, Chemotherapy
Publications
Case Report Open Access
Successful Treatment with Rituximab of Sjögren’s Syndrome-Associated Organizing Pneumonia in a Patient Treated with PD-L1 Blockade for Ovarian Cancer
Author(s): Angela Orcurto, Karim Abdelhamid, Claire Perrinjaquet, Benita Wolf, Cecile Daccord, Stephanie Viguet-Carrin, Stefan Zimmermann, George Coukos and Denis Comte
As the use of immune checkpoint inhibitors in cancer therapy increases across a wide range of tumor types, rarer toxicities including rheumatologic immune adverse events are reported with increasing frequency. We describe the case of an ovarian cancer patient treated with durvalumab, who developed an organizing pneumonia, proved to be related to a preexisting but previously unknown asymptomatic Sjögren’s syndrome, confirmed by a positive antibody (anti-SSA and anti-SSB) panel. While resistant to corticosteroids, was ultimately successfully treated with the B-cell depleting antibody rituximab with no impact on the anticancer therapy efficacy. This case shows that patients with preexisting autoimmune diseases should not be systematically excluded from potentially life-saving an... view more»
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