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Hindi Journal of Clinical & Experimental OncologyISSN: 2324-9110
Braumann C Author
Subjects of specialization
Affiliation
Colorectal cancer, Cancer chemotherapy, Prostate biomarker, Endometrial cancer
Department of General and Visceral Surgery, St. Josef-Hospital, Ruhr- University Bochum, Germany
Biography
Braumann C was working in the Department of General and Visceral Surgery, St. Josef-Hospital, Ruhr- University Bochum, Germany. He has more than 150 publications. His current research area related to osteoarthropathy
Publications
Research Article Open Access
Single Versus Double Ring Structure: Search for Best Anti-Neoplastic Driver in Colon and Pancreatic Cancer Cells-Taurultam or Taurolidine?
Author(s): Buchholz M*, Berg J, Braumann C, Majchrzak-Stiller B, Hahn S, Pfirrmann RW, UhI W and Chromik AM
Background: Since the molecular mechanism of the well-known anti-infective and antineoplastic substance Taurolidine (TRD) is still unknown, we sought to analyze the anti-neoplastic capacity of its main metabolite Taurultam (TAU) in malignant human cell lines derived from pancreatic cancer (AsPC-1, BxPC-3, HPAF II, MiaPaca-2, Panc-1) and colon cancer (SW-480, HT-29 and HCT-116) in vitro.
Methods: Cell lines were incubated with TAU or TRD in increasing concentrations for 24h and 48h. Comprehensive analyses were performed to quantify the anti-neoplastic activity of TAU: Analysis of cytotoxicity via MTT-assay, inhibition of proliferation via BrdU and induction of apoptosis and necrosis via FACS-analysis. Furthermore, cell growth was monitored usin... view more»
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