C M Manjusha Author

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Synthesis, Characterization and In Vitro Assessment of Gellan Gum Tamoxifen Citrate Macrobeads and Nanoparticles

Author(s):

C M Manjusha , S Soumiya and A Santhiagu

Objective: Tamoxifen citrate drug (Brand name: Nolvadex), a Selective Estrogen Receptor Modulator (SERM) is a nonsteroidal triphenylethylene derivative with poor solubility and low oral bioavailability. In the present work, an attempt was made to develop a novel system of Tamoxifen citrate encapsulated macrobeads and nanoparticles using a recombinant Gellan gum synthesized. Method: Gellan gum drug macrobead combination was prepared using the ionotropic gelation method and its nanoparticle was synthesized by emulsion cross-linking technology. Result: The results showed that Gellan gum Tamoxifen citrate nanoparticles were found to be more efficient in encapsulation than Gellan gum Tamoxifen citrate macro-beads. Gellan gum Tamoxifen citrate nanoparticles demonstrated a greater drug release... view more»

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