Journal of Immunological Techniques & Infectious Diseases ISSN: 2329-9541

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Challu V Author

vijaya@mcbl.iisc.ernet.in 91-80-22932685 | 91-80-229326

Subjects of specialization
Mycobacterium tuberculosis; Rv3881c; Human polyfunctional T cells; Guinea pig model; Experimental vaccine

Affiliation
National Tuberculosis Institute, 8, Bellary Road, Bangalore, Karnataka 560003, India

Biography

Dr. Challu V was an Assistant Professor of National Tuberculosis Institute, 8, Bellary Road, Bangalore, Karnataka 560003, India and later he started working on Rv3881c from Mycobacterium tuberculosis Elicits PolyFunctional CD8+ T cells in PPD Positive Healthy Volunteers and Affords Significant Protection in the Guinea Pig Model

Publications

Research Article Subscription

Rv3881c from Mycobacterium tuberculosis Elicits PolyFunctional CD8+ T cells in PPD Positive Healthy Volunteers and Affords Significant Protection in the Guinea Pig Model

Author(s):

Satchidanandam V, Kumar N , Biswas S, Jumani RS, Jain C, Rani R, Aggarwal B, Singh J, Kotnur MR, Challu V, Chadha VK, Kumar P and Sridharan A

We show that Rv3881c, a secreted protein of M. tuberculosis (MTB), elicits T cell responses from healthy PPD-positive individuals and TB patients. Synthetic peptides spanning the complete length of Rv3881c induced secretion of significantly greater levels of TNF-α and IL-10 from peripheral blood mononuclear cells of TB patients compared to latently infect healthy volunteers. Polychromatic flow cytometry detected poly-functional CD4+ and CD8+ T cells secreting different combinations of IFN-γ, TNF-α, IL-2 and MIP-1β in response to Rv3881c. Lev... view more»

DOI: 10.4172/2329-9541.1000138

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