Chekashkina KV Author

Short Communication Open Access

Membrane Lipid Oxidation as a Negative Feedback Loop Modulating Cell Response to Oxidative Stress

Author(s):

Chekashkina KV, Bashkirov PV and Pavlov KV*

Reactive oxygen species (ROS) are implicated in originating multiple deleterious processes, including inflammation of the airways, heart diseases, carcinogenesis, age-related neurodegenerative conditions, etc. Less commonly discussed are the beneficial and/or inevitable effects associated with their normal production in healthy cells and tissues. Lipid oxidation by ROS can be viewed as playing a dual role, including upregulation of certain proteins required for the protection of cells and tissues against abnormally high ROS concentrations, thereby constituting a negative feedback loop required for dynamic stability of homeostasis. Analysis of recent publications and the original experimental results provide convincing, if circumstantial, evidence in support ... view more»

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