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Hindi Journal of Pharmaceutics & Drug Delivery ResearchISSN: 2325-9604
Chetan M. Bhalgat Author
Subjects of specialization
Affiliation
Human brucellosis;
S.A.C. College of Pharmacy, B.G. Nagara 571448, Nagamangala (Tq), Mandya Dist., Karnataka, India
Biography
My name is Chetan M. Bhalgat I am from S.A.C. College of Pharmacy, B.G. Nagara 571448, Nagamangala (Tq), Mandya Dist., Karnataka, India My area of interests are Human brucellosis;
Publications
Research Article Subscription
Application of an LC-MS/MS Method in Quantification of Hexyl Chloroformate Content in Dabigatran Etexilate Mesylate
Author(s): Rakesh Kumar Yadav, Jayvant Harlikar, Jaidatta Deshmukh, Chetan M. Bhalgat, Dipak Thange, Hemant Birari, Manish Gangrade, Srinivas V Pullela and Vinod Acharya
Application of an LC–MS/MS Method in Quantification of Hexyl Chloroformate Content in Dabigatran Etexilate Mesylate
Abstract
A selective and sensitive liquid chromatography–mass spectrometry (AB SCIEX QTRAP 5500) method was developed for quantitative determination of genotoxic impurity, hexyl chloroformate, in drug substance. The method was developed by derivatizing the hexyl chloroformate (HCF) to complex compound hexyl benzylcarbamate (HBC) by reaction with benzylamine. This method provided good sensitivity for quantification of hexyl chloroformate at a concentration of 10 ppm in 10 mg/mL... view more»
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