Christdas J Author

Research Article Subscription

Occurrence of Escape Favoring Mutations in The Targets of 2F5 and 4E10 Antibodies of HIVgp41 : A Metadata Analysis

Author(s):

Christdas J and Shakila H

Objective

The preventive vaccine for HIV has been an unachieved goal and the increasing prevalence burdens the field of medicine for the last three decades. The challenge is due to the substantial overall sequence variability that is found across the genome of HIV- 1. Here a retrospection has been done to investigate the degree of conservation in the targets of the 2F5 and 4E10 neutralizing antibodies. The 6 and 7 amino acid long epitopes of the neutralizing antibodies are embedded in the MPER (Membrane Proximal External Region) of the HIV-1 glycoprotein 4... view more»

DOI: 10.4172/2324-8955.1000141

Abstract HTML PDF