Confidence Onyebuchiand Doga Kavaz Author

Annual Meeting Abstract Open Access

Optimized synthesis, characterization, antioxidative, antibacterial, anticancer cells proliferation and in vitro release kinetics study of chitosan and N, N, N-trimethyl chitosan nanoparticles loaded with Ocimum gratissimum essential oil

Author(s):

Confidence Onyebuchi and Doga Kavaz

The low solubility, loss of mucoadhesivity and poor absorption property of chitosan (CS) at physiological pH limits its applicability in biomedical and pharmaceutical field. N,N,N-Trimethyl Chitosan (TMC) have shown enhanced penetration property, well-defined structure and improved solubility over wide pH range. Ocimum gratissimum Essential Oils (OGEOs) and methanolic extracts (OGEO-MeOH) have known bioactivity. Chemical qualitative analysis of the extracts by Gas Chromatography-Mass Spectrometry (GC-MS) showed newly found compounds not previously reported for OGEO such as eicosane, heneicosane, triphenylphosphine oxide, 1-acetyl-2methyl-2-cycloppentene, (E)-9-octadecenoic acid, 2-carene, andgamma-terpinene.
Different methods and optimized technique were adopted for the successfu... view more»

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