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Dana Napier Author
Subjects of specialization
Affiliation
Surgery , Cancer, Molecular Tumor, Targeted Therapy
Markey Tumor Procurement Faculty, Markey Cancer Center, University of Kentucky College of Medicine, Lexington, Kentucky
Biography
Dr. Dana Napier has been working in the Markey Tumor Procurement Faculty, Markey Cancer Center, University of Kentucky College of Medicine, Lexington, Kentucky. Dr. Napier specializes in the field of Surgery, Cancer, Molecular Tumor, Targeted Therapy .
Publications
Case Report Subscription
A Case Study of Precision Medicine: Next Generation Sequencing Compared with Oncoscan in a Patient with Breast Cancer in Kentucky
Author(s): Rolf J Craven*, Kuey-Chu Chen, Steven Schwarze, Sydney Lay, Dana Napier and Rachel Stewart
Purpose: Precision medicine of tumors is designed to tailor treatment combinations to individual patients, targeting specific genotypes with corresponding inhibitors. The purpose of this study was to determine whether genotype predicted target gene expression-a critical parameter for treatment-and to test whether alternate modes of gene amplification could affect gene expression. Patients and methods: The cohort consisted of patients in Kentucky with recurrent breast cancer who were analyzed by nextgeneration sequencing. Tumors with amplifications in CCND1, AURKA, and MYC were then stained by immunohistochemistry. We subsequently selected a patient with triple-negative breast cancer for analysis by FISH, immunohistochemistry and OncoScan genome-wide copy number array. Results: The exten... view more»
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