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Hindi Endocrinology & Diabetes ResearchISSN: 2470-7570
1Delcheva Author
Subjects of specialization
Affiliation
Type 1 diabetes mellitus
Department of Biochemistry, Faculty of Pharmacy, Medical University
Biography
The development of atherosclerosis is a multifactorial process, but oxidized low-density lipoprotein (oxLDL) has been recognized as a critical player in the pathogenesis of the disease. The lectin-like oxLDL receptor-1 (LOX-1) has recently been identified as the primary scavenger receptor of oxLDL, which mediates their detrimental biological effects in endothelial cells
Publications
Special Issue Article Open Access
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) and soluble LOX-1 (sLOX-1): implications in atherosclerosis-related diseases
Author(s): 1*Stankova, T.R., 1Stefanova, K.I., 1Delcheva, G.T. & 1 Maneva, A.I.
The development of atherosclerosis is a multifactorial process, but oxidized low-density lipoprotein (oxLDL) has been recognized as a critical player in the pathogenesis of the disease. The lectin-like oxLDL receptor-1 (LOX-1) has recently been identified as the primary scavenger receptor of oxLDL, which mediates their detrimental biological effects in endothelial cells. Subsequent studies have revealed that LOX-1 is also expressed by other cells highly implicated in atherosclerosis, such as monocytes/macrophages, vascular smooth muscle cells, cardiomyocytes and platelets. On one hand interaction of oxLDL with LOX-1 promotes oxidative stress and transcription of pro-inflammatory molecules, and on the other hand increases the expression of LOX-1 as a result of the vicious cycle, activate... view more»
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