Dhaval J Patel Author

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Physicochemical Characterization and In-Vitro Dissolution Enhancement of Bicalutamide-Hp-Î’-Cd Complex

Author(s):

Brijesh Kantilal Vaniya ,Shrenik K Shah, Dhaval J Patel and Hiren N Khatri

Abstract:

Inclusion complex has been used as effective metllhod to improve the dissolution properties and bioavailability of poorly water soluble drugs. The aim of present study was to improve the dissolution rate of poorly soluble drug, bicalutamide (BIC), by cyclodextrin inclusion complexation. The phase solubility profile of bicalutamide with hydroxypropyl-β-Cyclodextrin (HP- β-CD) was classified as An-type. Stability constant with 1:2 molar ratio was calculated from the phase solubility diagram. Gibbs free energy (ΔGtr) values were negative, indicating the spontaneous nature of BIC solubilization. Solid inclusion complexes were prepared at 1:1.5, 1:2 drug/carrier ratio by physical mixi... view more»

DOI: 10.4172/2325-9604.1000126

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