Clinical Oncology: Case Reports

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Dmytro Kovalskyy Author

Subjects of specialization
cancer, cancer oncology, Carcinogenesis, Cheminformatics and Computational Chemistry Drug Discovery Medicinal and Pharmaceutical Chemistry Virtual Screening Molecular Docking Molecular Modeling Docking Studies Homology Modeling Computational Chemistry Molecular Dynamics Simulation

Affiliation
Department of Biochemistry, University of Texas Health Science Center San Antonio, Texas, United States of America

Biography

Dr. Dmytro Kovalskyy is working as scientist and professor at Department of Biochemistry, University of Texas Health Science Center San Antonio, Texas, United States of America. The author has specalization in cancer, cancer oncology, chemotherapy, Carcinogenesis, Chemotherapy,Cheminformatics and Computational Chemistry Drug Discovery Medicinal and Pharmaceutical Chemistry Virtual Screening Molecular Docking Molecular Modeling Docking Studies Homology Modeling Computational Chemistry Molecular Dynamics Simulation


Publications

Case Report Subscription

Metastatic Thymic Carcinoma with novel KIT mutations masquerading as a Carcinoma of Unknown Primary Site

Author(s):

Gabriel Roman Souza, Sarah Hackman, Kayla E Chamberlin, Dmytro Kovalskyy, Amy L Mumbower and Daruka Mahadevan

A patient diagnosed with thymic carcinoma was found to have three KIT mutations (F522C, V560del, and Y823S), two of them not previously documented. In addition, this is the first reported case of thymic carcinoma with more than one pathogenic KIT mutation. He was initially treated with imatinib mesylate (IM) with a minor response. Subsequently, IM was discontinued, and he was treated with cisplatin plus gemcitabine with clinical and radiologic response. A repeat liquid biopsy showed total suppression of V560del, Y823S, F522C, and KRAS amplification.

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