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Hindi Journal of Clinical & Experimental OncologyISSN: 2324-9110
Eiji Shinto# Author
Subjects of specialization
Affiliation
Colorectal cancer, Cancer chemotherapy, Prostate biomarker, Endometrial cancer
Surgery, National Defense Medical College, Saitama, Japan
Biography
Eiji Shinto was working in the Surgery, National Defense Medical College, Saitama, Japan. Doctor has more than 40 publications. Doctor's current research area related to osteoarthropathy. Doctor was specialised in Cancer chemotherapy.
Publications
Research Article Open Access
Prognostic Model of Stage II/III Colon Cancer Constructed using Gene Expression Subtypes and KRAS Mutation Status
Author(s): Kengo Gotoh#, Eiji Shinto#, Yuichiro Yoshida*, Hideki Ueno,Yoshiki Kajiwara, Masato Yamadera, Ken Nagata, Hitoshi Tsuda, Junji Yamamoto and Kazuo Hase
Objectives: Cancer subtypes classified according to DNA microarray data predict prognosis with high accuracy. Here we constructed a new colon cancer (CC) subtype classification based on only of genes with known biological functions with the aim of establishing a new prognostic model for clinical use.
Methods: We performed an expression correlation analysis using data for 73 primary CC cases in the public dataset (learning set), focusing on genes located on the long arms of chromosomes 18 and 20 and stromal-related genes. We determined the representation of each gene in the modules with closely correlated expression levels in the same module. Mutations in KRAS, BRAF and TP53 were assessed ... view more»
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