Eswari Loganathan Author

Research Article Open Access

IL 17 Cytokine in Psoriasis: Before and After Methotrexate and NBUVB Phototherapy: A Longitudinal Study

Author(s):

Leelavathy Budamakuntla, Eswari Loganathan, Pavithra Gundappa, Sreelakshmi and Tapasya Kini and Kavya K

Background: Psoriasis, a disease of abnormal epidermal proliferation, was found to be T helper-1 disease. Currently a new concept of T Helper 17 has been found to play a major role through
IL-17 and IL-22 cytokines in the disease pathogenesis.
Aim: Since IL 17 is one of the key effector cytokine of Th17 pathway, we conducted a 12 week longitudinal study of effect of NBUVB phototherapy and Methotrexate on serum IL 17 levels in patients with psoriasis before and after treatment.
Materials and Methods: This was a prospective longitudinal study done on 28 psoriasis patients with PASI>10 and 10 controls. Serum IL-17 levels and PASI scoring was estimated at baseline and after 12 weeks after t... view more»

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