Fernaacute;ndez-Torrres Javier | Author | SciTechnol

Fernaacute;ndez-Torrres Javier Author

jimenezce@yahoo.com.mx +52-5588-4019 | +52-5588-401

Subjects of specialization
Type 1 diabetes mellitus, Hypoxia inducible factor-1 ?

Affiliation
Sinovioanalisis Molecular Laboratory, National Institute of Rehabilitation, Secretary of Health, Calzada Mexico-Xochimilco 289, Arenal de Guadalupe, Mexico DF 14389, Tlalpan, M

Biography

Fernaacute;ndez-Torrres Javier Sinovioanalisis Molecular Laboratory, National Institute of Rehabilitation, Secretary of Health, Calzada Mexico-Xochimilco 289, Arenal de Guadalupe, Mexico DF 14389, Tlalpan, México. His publication include: 1.Ounissi-Benkalha H, Polychronakos C (2008) The molecular genetics of type 1 diabetes: new genes and emerging mechanisms. Trends Mol Med 14: 268-275. 2.Gu HF1, Zheng X, Abu Seman N, Gu T, et al. (2013) Impact of the hypoxia-inducible factor-1 α (HIF1A) Pro582Ser polymorphism on diabetes nephropathy. Diabetes Care 36: 415-421.

Publications

Research Article Open Access

Hypoxia Inducible Factor-1Î± Gene rs11549465 Might be Protective Factor for the Development of Type 1 Diabetes Mellitus

Author(s):

Crisostomo-Vázquez María del Pilar, Fernández-Torrres Javier, Maravelez-Acosta VictorAlberto, Medina-Bravo Patricia, López-Reyes Alberto3, Granados Julio and Jiménez- Cardoso Enedina

Introduction: Pancreas is a highly vascularized tissue which makes oxygen a fundamental element for its metabolism. As a consequence of the variations in its delivery, the expression of genes that maintain homeostatic levels of oxygen supply a regulated by hypoxia-inducible factor 1 α (HIF-1α). Here we tested the role of single nucleotide polymorphism (SNP) of HIF-1α as markers for susceptibility or protection to develop pancreatic injury in Mexican patients with type 1 diabetes mellitus (T1DM).
Methods: We studied 55 patients with T1DM that conformed to the criteria of the American Diabetes Association (ADA); in them, we extracted DNA from peripheral blood cells and studied the gene that encodes HIF-... view more»

DOI: 10.4172/2470-7570.1000131

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